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Titolo:
DOPAMINE D-4 RECEPTOR AND ANXIETY - BEHAVIORAL PROFILES OF CLOZAPINE,L-745,870 AND L-741,742 IN THE MOUSE PLUS-MAZE
Autore:
CAO BJ; RODGERS RJ;
Indirizzi:
UNIV LEEDS,SCH PSYCHOL,ETHOPHARMACOL LAB LEEDS LS2 9JT W YORKSHIRE ENGLAND UNIV LEEDS,SCH PSYCHOL,ETHOPHARMACOL LAB LEEDS LS2 9JT W YORKSHIRE ENGLAND
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 335, anno: 1997,
pagine: 117 - 125
SICI:
0014-2999(1997)335:2-3<117:DDRAA->2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC AGENT; HIGH-AFFINITY; SELECTIVE ANTAGONIST; ETHOLOGICAL ANALYSIS; CONDITIONED FEAR; 5-HT1A RECEPTORS; SQUIRREL-MONKEYS; D4 RECEPTORS; MICE; OLANZAPINE;
Keywords:
ANXIETY; ELEVATED PLUS-MAZE; CLOZAPINE; L-745,870 L)PIPERAZIN-1-YL]METHYL)-1H-PYRROLO[2,3B]PYRIDINE); HYL-3-(1-(2-PHENYLETHYL)PIPERIDINE-4-YL)ISOXAZOLE); DOPAMINE D-4 RECEPTOR; CHLORDIAZEPOXIDE; MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Cao e R.J. Rodgers, "DOPAMINE D-4 RECEPTOR AND ANXIETY - BEHAVIORAL PROFILES OF CLOZAPINE,L-745,870 AND L-741,742 IN THE MOUSE PLUS-MAZE", European journal of pharmacology, 335(2-3), 1997, pp. 117-125

Abstract

The dopamine D-4 receptor has been implicated in the therapeutic effects of the atypical antipsychotic, clozapine. As it has been proposed that anxiolytic-like activity may contribute to the efficacy of this agent in ameliorating the negative symptoms of schizophrenia, the current study employed ethological methods to fully characterize the acute behavioural profiles of clozapine and two more selective dopamine D-4 receptor antagonists, L-745,870 )piperazin-1-yl)]methyl)-1H-pyrrolo[2,3b]pyridine) and L-741,742 hyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole), in the mouse elevated plus-maze test. Results showed that while clozapine (0.3-6.0 mg/kg) dose-dependently inhibited all active behaviours (arm entries, exploration, rearing) and increased grooming and immobility, it failed to alter the major anxiety indices (percent openentries and open time). In contrast, L-745,870 (0.02-1.5 mg/kg) and L-741,742 (0.04-5.0 mg/kg) did not produce any significant behavioural changes under present test conditions. These data, which contrast markedly with the robust anxiolytic profile of the reference compound, chlordiazepoxide (10.0 mg/kg), provide little support for the suggestion that clozapine possesses anxiolytic-like properties and further indicate that selective dopamine D, receptor antagonists are ineffective in the modulation of anxiety-related behaviours in the plus-maze. (C) 1997 Elsevier Science B.V.

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Documento generato il 21/01/20 alle ore 01:02:18