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Titolo:
EFFECTS OF TAMM-HORSFALL PROTEIN WITH NORMAL AND REDUCED SIALIC-ACID CONTENT UPON THE CRYSTALLIZATION OF CALCIUM-PHOSPHATE AND CALCIUM-OXALATE IN HUMAN URINE
Autore:
HALLSON PC; CHOONG SKS; KASIDAS GP; SAMUELL CT;
Indirizzi:
UNIV COLL LONDON,DEPT CHEM PATHOL,SCH MED,CLEVELAND ST,WINDEYER BLDG LONDON W1P 6DB ENGLAND UNIV COLL LONDON,INST UROL & NEPHROL,SCH MED LONDON W1P 6DB ENGLAND
Titolo Testata:
British Journal of Urology
fascicolo: 4, volume: 80, anno: 1997,
pagine: 533 - 538
SICI:
0007-1331(1997)80:4<533:EOTPWN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRYSTAL-FORMATION; STONE FORMATION; RENAL STONES; WHOLE URINE; GLYCOPROTEIN;
Keywords:
TAMM-HORSFALL PROTEIN; SIALIC ACID; URINARY CRYSTALS; CALCIUM PHOSPHATE AND OXALATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Hallson et al., "EFFECTS OF TAMM-HORSFALL PROTEIN WITH NORMAL AND REDUCED SIALIC-ACID CONTENT UPON THE CRYSTALLIZATION OF CALCIUM-PHOSPHATE AND CALCIUM-OXALATE IN HUMAN URINE", British Journal of Urology, 80(4), 1997, pp. 533-538

Abstract

Objective To examine the effects of Tamm-Horsfall protein (THP) of normal and low sialic acid content on urinary crystallization, and establish whether there are changes conducive to the formation of kidney stones. Materials and methods Purified samples of THP were recovered from the urine of non-stone forming individuals. A portion of each THP sample was treated with the enzyme neuraminidase to yield the low sialicacid form of the protein. The two forms of THP were added separately to ultrafiltered urine and crystallization was then induced in the urine by evaporation at 37 degrees C. Two types of experiment were then conducted with the crystals that formed; the rate at which the resulting calcium phosphate or calcium oxalate crystals sedimented in the evaporated urine was determined and the proportion of these crystals and protein which was retained when the urine was passed through a 75 mu m sieve was measured. Results Calcium phosphate and calcium oxalate crystals remained in stable colloidal suspension in ultrafiltered urine when in the presence of normal THP; these suspensions passed freely through the 75 mu m sieves. When crystals formed in the presence of low sialic acid THP, the sedimentation was rapid and the crystals were readily retained with protein on the sieves. Conclusions These results indicate that whilst normal THP inhibits urinary crystal aggregation, the properties of the low sialic acid form are consistent with the promotion of crystal aggregation and hence stone formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 07:14:43