Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
5-HT2C RECEPTOR ACTIVATION DECREASES APPETITE AND BODY-WEIGHT IN OBESE SUBJECTS
Autore:
SARGENT PA; SHARPLEY AL; WILLIAMS C; GOODALL EM; COWEN PJ;
Indirizzi:
UNIV OXFORD,LITTLEMORE HOSP,DEPT PSYCHIAT OXFORD OX4 4XN ENGLAND UNIV OXFORD,LITTLEMORE HOSP,DEPT PSYCHIAT OXFORD OX4 4XN ENGLAND
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 133, anno: 1997,
pagine: 309 - 312
Fonte:
ISI
Lingua:
ENG
Soggetto:
META-CHLOROPHENYLPIPERAZINE; LOCOMOTOR-ACTIVITY; HUMAN VOLUNTEERS; SEROTONIN; CPP; NEUROENDOCRINE; TEMPERATURE; HYPOPHAGIA; ANTAGONIST; TOLERANCE;
Keywords:
MCPP; 5-HT RECEPTOR; BODY WEIGHT; OBESITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Sargent et al., "5-HT2C RECEPTOR ACTIVATION DECREASES APPETITE AND BODY-WEIGHT IN OBESE SUBJECTS", Psychopharmacology, 133(3), 1997, pp. 309-312

Abstract

We studied the effect of 2 weeks administration of the 5-HT2C receptor agonist, m-chlorophenylpiperazine (mCPP), on appetite and body weight in 18 moderately obese subjects in a double-blind, placebo-controlled trial. mCPP caused a small but significant (0.75 kg) reduction in body weight and in subjective ratings of hunger, Plasma prolactin was significantly elevated by the final dose of mCPP. Our data suggest that during 2 weeks treatment in humans, mCPP may continue to activate brain 5-HT2C receptors, and that this effect is associated with decreases in appetite and body weight.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:42:40