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Titolo:
HALOPERIDOL ENHANCES LATENT INHIBITION IN VISUAL TASKS IN HEALTHY PEOPLE
Autore:
WILLIAMS JH; WELLMAN NA; GEANEY DP; FELDON J; COWEN PJ; RAWLINS JNP;
Indirizzi:
UNIV OXFORD,DEPT EXPT PSYCHOL,S PARKS RD OXFORD OX1 3UD ENGLAND UNIV OXFORD,DEPT EXPT PSYCHOL OXFORD OX1 3UD ENGLAND UNIV OXFORD,DEPT PHARMACOL OXFORD OX1 3UD ENGLAND UNIV OXFORD,DEPT PSYCHIAT OXFORD OX1 3UD ENGLAND INST TOXICOL ZURICH SWITZERLAND
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 133, anno: 1997,
pagine: 262 - 268
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC ATTENTION DISORDER; PRONE NORMAL SUBJECTS; D-AMPHETAMINE; IRRELEVANT STIMULI; NUCLEUS-ACCUMBENS; RATS ABILITY; MODEL; PREEXPOSURE; CLOZAPINE; DOPAMINE;
Keywords:
LATENT INHIBITION; HALOPERIDOL; ANTIPSYCHOTIC DRUGS; HEALTHY VOLUNTEERS; SCHIZOTYPY; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Williams et al., "HALOPERIDOL ENHANCES LATENT INHIBITION IN VISUAL TASKS IN HEALTHY PEOPLE", Psychopharmacology, 133(3), 1997, pp. 262-268

Abstract

We have previously shown that 0.5 mg haloperidol (IV) increased latent inhibition in one of two visual tasks, The present study analysed the effects of a higher dose of haloperidol (1.0 mg, IV) on latest inhibition in these two visual tasks in healthy volunteers in a randomised controlled trial. In the task where 0.5 mg haloperidol had enhanced latent inhibition, 1.0 mg had the same effect, thus replicating the previous result, In the task where 0.5 mg haloperidol had been ineffective, 1.0 mg haloperidol enhanced latent inhibition in high schizotypal subjects only. This indicates that subjects with higher schizotypy scores are more sensitive to dopamine blockade. A comparison of the resultsfrom the studies at the two different doses suggests a dose dependence of haloperidol's effects on latent inhibition that parallels resultsfrom animal work.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:29:13