Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IS THE BONE MASS OF HEMODIALYSIS-PATIENTS GENETICALLY-DETERMINED
Autore:
AKIBA T; ANDO R; KURIHARA S; HEISHI M; TAZAWA H; MARUMO F;
Indirizzi:
TOKYO MED & DENT UNIV,DEPT INTERNAL MED,BUNKYO KU,1-5-45 YUSHIMA TOKYO 113 JAPAN TOKYO MED & DENT UNIV,KIDNEY CTR TOKYO 113 JAPAN NAKANO GEN HOSP,DEPT INTERNAL MED TOKYO JAPAN KASUKABE SHUWA HOSP,DEPT NEPHROL KASUKABE SAITAMA JAPAN SUMITOMO MET BIOSCI SAGAMIHARA KANAGAWA JAPAN
Titolo Testata:
Kidney international
, volume: 52, anno: 1997, supplemento:, 62
pagine: 69 - 71
SICI:
0085-2538(1997)52:<69:ITBMOH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D-RECEPTOR; HYPERPARATHYROIDISM; ALLELES; DENSITY;
Keywords:
BONE MASS; HEMODIALYSIS; GENETICS; UREMIA; VITAMIN-D; OSTEOPOROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
T. Akiba et al., "IS THE BONE MASS OF HEMODIALYSIS-PATIENTS GENETICALLY-DETERMINED", Kidney international, 52, 1997, pp. 69-71

Abstract

Polymorphism of the vitamin D receptor gene (VDR) has been linked to bone mineral density in twins, postmenopausal osteoporosis, and premenopausal woman. We examined the possibility that the bone mass in hemodialysis (HD) patients might be determined by VDR. The study consisted of 229 HD patients with a mean age of 53.3 years (range 21 to 83), whowere dialyzed three times a week fur an average of 8.65 (range 0.2 to24) years. We determined their VDR using DNA of peripheral white blood cells by restriction enzyme BsmI and the polymerase chain reaction-restriction fragment length polymorphism method. Bone mineral content (BMC) was estimated at 1/3 of the radius using dual energy X-ray bone absorptiometry, and expressed in z-scores standardized by gender and age. Distributions of VDR in this hemodialysis population were BE (9.9%), Bb (13.1%), and bb (77.0%), showing no significant different from those in 105 healthy volunteers (BE, 7.6%; Bb, 13.3%; and bb, 79.0%). Multiple regression analysis revealed that gender, age, duration on HD, and serum osteocalcin are major determinants of BMC (r = 0.762, P < 0.001), while VDR and serum parathyroid hormone are not. In a subgroup with younger (< 65 years) patients dialyzed for less than 8.65 years, the z-score of BMC of patients with BE allele was less than those with Bb and bb allele (N = 77, P = 0.020). We conclude that vitamin D receptor polymorphism is not one of the main determinants of BMC of HD patients, though it might partially effect bone mass in a subgroup of younger HD patients with shorter HD histories. Further studies with longitudinal observation will be needed to confirm these possibilities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:02:19