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Titolo:
EFFECTS OF CLOZAPINE ON PLASMA-CATECHOLAMINES AND RELATION TO TREATMENT RESPONSE IN SCHIZOPHRENIA - A WITHIN-SUBJECT COMPARISON WITH HALOPERIDOL
Autore:
BROWN AS; GEWIRTZ G; HARKAVYFRIEDMAN J; COOPER T; BREBION G; AMADOR XF; MALASPINA D; GORMAN JM;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,NEW YORK STATE PSYCHIAT INST,DEPT PSYCHIAT,722 W 168TH ST,UNIT 2 NEW YORK NY 10032 NATHAN S KLINE INST PSYCHIAT RES ORANGEBURG NY 10962
Titolo Testata:
Neuropsychopharmacology
fascicolo: 5, volume: 17, anno: 1997,
pagine: 317 - 325
SICI:
0893-133X(1997)17:5<317:EOCOPA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; RESISTANT SCHIZOPHRENIA; HOMOVANILLIC-ACID; NOREPINEPHRINE; DOPAMINE; FLUPHENAZINE; PROLACTIN; EFFICACY; IDAZOXAN;
Keywords:
CLOZAPINE; SCHIZOPHRENIA; NOREPINEPHRINE; HOMOVANILLIC ACID; SYMPTOMATOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A.S. Brown et al., "EFFECTS OF CLOZAPINE ON PLASMA-CATECHOLAMINES AND RELATION TO TREATMENT RESPONSE IN SCHIZOPHRENIA - A WITHIN-SUBJECT COMPARISON WITH HALOPERIDOL", Neuropsychopharmacology, 17(5), 1997, pp. 317-325

Abstract

We conducted a within-subject comparison of the effects of clozapine and haloperidol on plasma levels of neurotransmitters and metabolites,and related changes in specific plasma neurochemicals with clozapine response. The subjects were 14 inpatients with schizophrenia or schzoaffective disorder, who were refractory to haloperidol and at least oneother typical antipsychotic medication. Subjects underwent, in the following order: a 6-week ''fixed, flexible dose'' haloperidol trial, followed by a 2-4 week medication-free phase, and a 6-week clozapine trial. Plasma levels of norepinephrine (NE), homovanillic acid (HVA), and3-methoxy-4-hydroxyphenylglycol (MHPG), and objective clinical ratings of total, positive, negative, and depressive symptoms wee obtained at the end of each phase. As expected, we found a substantial increase of plasma NE with clozapine but not with haloperidol. However, the increase in NE was not associated with improvement in total or positive symptomatology. There was some evidence for an association between improvement in negative symptoms and increased HVA on clozapine, as well as diminished HVA during the medication-free phase. The implications ofthese data for understanding the mechanisms of action of clozapine are discussed. (C) 1997 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 04/04/20 alle ore 08:59:28