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Titolo:
IN-VIVO IMAGING OF NEUROTRANSMITTER SYSTEMS USING RADIOLABELED RECEPTOR LIGANDS
Autore:
KEGELES LS; MANN JJ;
Indirizzi:
722 W 168TH ST,BOX 28 NEW YORK NY 10032 NEW YORK STATE PSYCHIAT INST & HOSP,DEPT NEUROSCI NEW YORK NY 10032 COLUMBIA UNIV,DEPT PSYCHIAT NEW YORK NY 00000
Titolo Testata:
Neuropsychopharmacology
fascicolo: 5, volume: 17, anno: 1997,
pagine: 293 - 307
SICI:
0893-133X(1997)17:5<293:IIONSU>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NAIVE SCHIZOPHRENIC-PATIENTS; LIVING HUMAN-BRAIN; CEREBRAL GLUCOSE-UTILIZATION; STRIATAL DOPAMINE RELEASE; IN-VIVO; ENDOGENOUS DOPAMINE; HIGH-AFFINITY; BLOOD-FLOW; BENZODIAZEPINE RECEPTORS;
Keywords:
BRAIN IMAGING; LIGANDS; NEURORECEPTORS; NEUROTRANSMITTERS; POSITRON EMISSION TOMOGRAPHY; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
121
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Kegeles e J.J. Mann, "IN-VIVO IMAGING OF NEUROTRANSMITTER SYSTEMS USING RADIOLABELED RECEPTOR LIGANDS", Neuropsychopharmacology, 17(5), 1997, pp. 293-307

Abstract

In vivo functional brain imaging, including global blood flow, regional cerebral blood flow (rCBF), measured with positron emission tomography (PET) and single photon emission computed tomography (SPECT), and regional cerebral metabolic rate (rCMR) measured with deoxyglucose PET, have been widely used in studies of psychiatric disorders. These studies have found modest differences and required large numbers of patients. Activation studies using rCBF or rCMR as indices of neuronal activity are more sensitive because patients act as their own control; however, findings localize regions of change but provide no data about specific neurotransmitter systems. After a general discussion of the role of neurotransmitter systems in neuropsychiatric disorders, an overview of the methodology of development and selection of radioligands forPET and SPECT is presented. Studies involving PET and SPECT ligand methods are reviewed and their findings summarized, including recent work demonstrating successive mutual modulation of neurotransmitter systems. Kinetic and equilibrium analysis modeling are reviewed. the emerging methodology of measuring neurotransmitter release on activation, both pharmacologically and by task performance, using ligand methods is reviewed and proposed as a promising new approach for studying psychiatric disorders. (C) American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 26/01/20 alle ore 01:01:55