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Titolo:
ERYTHROCYTE AND PLASMA-LEVELS OF GLUTAMATE AND ASPARTATE IN CHILDREN AFFECTED BY MIGRAINE
Autore:
DEUFEMIA P; FINOCCHIARO R; LENDVAI D; CELLI M; VIOZZI L; TROIANI P; TURRI E; GIARDINI O;
Indirizzi:
POLICLIN UMBERTO 1,PEDIAT CLIN,VIALE REGINA ELENA 324 I-00161 ROME ITALY UNIV ROMA LA SAPIENZA,DEPT PEDIAT ROME ITALY
Titolo Testata:
Cephalalgia
fascicolo: 6, volume: 17, anno: 1997,
pagine: 652 - 657
SICI:
0333-1024(1997)17:6<652:EAPOGA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACIDS; AURA;
Keywords:
ASPARTATE; CORTICAL SPREADING DEPRESSION; GLUTAMATE; MIGRAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
P. Deufemia et al., "ERYTHROCYTE AND PLASMA-LEVELS OF GLUTAMATE AND ASPARTATE IN CHILDREN AFFECTED BY MIGRAINE", Cephalalgia, 17(6), 1997, pp. 652-657

Abstract

In this study we determined plasma and erythrocyte amino acids in children affected by migraine, in order to evaluate glutamate and aspartate metabolism in the pathogenesis of this disorder. Fifteen children with migraine with aura (mean age+/-SD=10.3+/-1.56), 19 children with migraine without aura (mean age+/-SD=10.4+/-1.48) and 16 healthy normalcontrols (mean age+/-SD 10.6+/-1.53) were investigated. In both migraine groups there were significantly lower plasma glutamate and aspartate levels and significantly higher erythrocyte/plasma concentration (E/P) ratios of these amino acids with respect to the controls. Erythrocyte aspartate concentrations were significantly elevated in migraine children compared to the controls, while erythrocyte glutamate concentrations showed no significant differences between groups. Similar results were observed in both migraine groups. These results seem to suggest the presence of a higher activity of the erythrocytes' glutamate/aspartate transport system that could reflect a similar alteration at theneuronal/glial cell level in the CNS. Our study suggests an imbalanceof the excitatory amino acid turnover in the pathogenesis of migrainein children.

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Documento generato il 23/09/20 alle ore 06:14:26