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Titolo:
PERIPHERAL VASCULAR EFFECTS AND PHARMACOKINETICS OF THE ANTIMIGRAINE COMPOUND, ZOLMITRIPTAN, IN COMBINATION WITH ORAL ERGOTAMINE IN HEALTHY-VOLUNTEERS
Autore:
DIXON RM; MEIRE HB; EVANS DH; WATT H; ON N; POSNER J; ROLAN PE;
Indirizzi:
ZENECA PHARMACEUT,CLIN PHARMACOL UNIT,ALDERLEY PK MACCLESFIELD SK10 2TG CHESHIRE ENGLAND WELLCOME RES LABS,DEPT CLIN PHARMACOL BECKENHAM BR3 3BS KENT ENGLAND UNIV LONDON KINGS COLL HOSP,DEPT ULTRASOUND LONDON ENGLAND UNIV LEICESTER,DEPT MED PHYS LEICESTER LE1 7RH LEICS ENGLAND
Titolo Testata:
Cephalalgia
fascicolo: 6, volume: 17, anno: 1997,
pagine: 639 - 646
SICI:
0333-1024(1997)17:6<639:PVEAPO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
THORACIC ELECTRICAL BIOIMPEDANCE; CORONARY CIRCULATION; STROKE VOLUME; SUMATRIPTAN; ARTERIES; MIGRAINE; AGONIST; DRUG;
Keywords:
ERGOTAMINE; MIGRAINE; PERIPHERAL VASCULATURE; PHARMACOKINETICS; ZOLMITRIPTAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Dixon et al., "PERIPHERAL VASCULAR EFFECTS AND PHARMACOKINETICS OF THE ANTIMIGRAINE COMPOUND, ZOLMITRIPTAN, IN COMBINATION WITH ORAL ERGOTAMINE IN HEALTHY-VOLUNTEERS", Cephalalgia, 17(6), 1997, pp. 639-646

Abstract

Members of the new class of antimigraine compounds, 5HT(1B/1D) agonists, as well as ergotamine, may cause vasoconstriction through stimulation of 5HT receptors on peripheral vessels. The cardiovascular effectsof 20 mg oral zolmitriptan (Zomig(TM), formerly 311C90), 2 mg oral ergotamine and the combination were assessed in a randomized double-blind, placebo-controlled crossover study in 12 healthy subjects. Pharmacodynamic measures included oscillometric blood pressure, systolic bloodpressure at the toe and arm using a strain gauge technique, stroke volume and cardiac output using bioimpedance cardiography, high-resolution ultrasound to measure brachial arterial diameter and a novel Doppler method to measure blood flow velocity. Both drugs produced small degrees of peripheral vasoconstriction, including increases in diastolic blood pressure and blood flow velocity and decreases in arterial diameter and toe-arm systolic pressure gradient. These effects were generally additive with the combination but of no clinical importance. There were no significant changes in cardiac output, stroke volume heart rate or ECG. Zolmitriptan, at eight times the Likely therapeutic dose, was generally well tolerated both alone and in combination with ergotamine. Ergotamine had no clinically important effects on zolmitriptan pharmacokinetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:32:40