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Titolo:
EFFECTS OF SUBCHRONIC ADMINISTRATION OF ANTIDEPRESSANTS AND ANXIOLYTICS ON LEVELS OF THE ALPHA-SUBUNITS OF G-PROTEINS IN THE RAT-BRAIN
Autore:
DWIVEDI Y; PANDEY GN;
Indirizzi:
UNIV ILLINOIS,DEPT PSYCHIAT,INST PSYCHIAT,COLL MED,1601 W TAYLOR ST CHICAGO IL 60612 UNIV ILLINOIS,DEPT PSYCHIAT,INST PSYCHIAT,COLL MED CHICAGO IL 60612
Titolo Testata:
Journal of neural transmission
fascicolo: 6-7, volume: 104, anno: 1997,
pagine: 747 - 760
SICI:
0300-9564(1997)104:6-7<747:EOSAOA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATED ADENYLATE-CYCLASE; INOSITOL PHOSPHOLIPID HYDROLYSIS; SEROTONIN RECEPTOR-BINDING; MESSENGER-RNA LEVELS; LONG-TERM LITHIUM; CEREBRAL-CORTEX; GTP-BINDING; CYCLIC-AMP; MEDIATED INHIBITION; SYSTEM;
Keywords:
ANTIDEPRESSANTS; ANXIOLYTICS; ANXIOGENICS; G PROTEINS; RAT BRAIN; IMMUNOLABELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
Y. Dwivedi e G.N. Pandey, "EFFECTS OF SUBCHRONIC ADMINISTRATION OF ANTIDEPRESSANTS AND ANXIOLYTICS ON LEVELS OF THE ALPHA-SUBUNITS OF G-PROTEINS IN THE RAT-BRAIN", Journal of neural transmission, 104(6-7), 1997, pp. 747-760

Abstract

The aim of this study was to examine the effects of subchronic administration of psychoactive drugs on the alpha subunits of G proteins in the rat brain, and also to determine if different classes of psychoactive drugs share a common property, i.e., of altering levels of these proteins. For this purpose, we selected the psychoactive drugs desipramine and phenelzine (antidepressants), lithium (antimanic), alprazolam and buspirone (anxiolytics), and metachlorophenylpiperazine (anxiogenic). The levels of alpha subunits of G proteins (G(s), G(i1/2), G(q/11)) expressed in cortical, hippocampal, and cerebellar brain regions were studied by the Western blot technique. We observed that subchronic treatment with lithium significantly decreased, and with phenelzine significantly increased levels of G(i1/2)alpha protein in the cortex and the hippocampus. On the other hand, buspirone significantly decreased levels of G(i1/2)alpha protein only in the cerebellum. Other psychoactive drugs, however, namely desipramine, meta-chlorophenylpiperazine, and alprazolam, did not alter levels of G(s), G(i1/2), G(q/11)alpha proteins in any of the brain regions studied. Since other studies have shown the involvement of G proteins in the mechanism of action of psychoactive drugs, our results demonstrate that expressed protein levels ofthe alpha subunit of G proteins are not altered by all the psychoactive drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:19:55