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Titolo:
TRISOMY-21 PLACENTAS - HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL FINDINGS USING PROLIFERATING CELL NUCLEAR ANTIGEN
Autore:
QURESHI F; JACQUES SM; JOHNSON MP; HUME RF; KRAMER RL; YARON Y; EVANS MI;
Indirizzi:
WAYNE STATE UNIV,DEPT PATHOL,HUTZEL HOSP,SCH MED,4707 ST ANTOINE BLVDDETROIT MI 48201
Titolo Testata:
Fetal diagnosis and therapy
fascicolo: 4, volume: 12, anno: 1997,
pagine: 210 - 215
SICI:
1015-3837(1997)12:4<210:TP-HAI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TROPHOBLASTIC DISEASE; MORPHOLOGY; FETUSES;
Keywords:
PLACENTA; GROWTH RETARDATION; PROLIFERATING CELL NUCLEAR ANTIGEN; HISTOPATHOLOGY; TRISOMY 21;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
F. Qureshi et al., "TRISOMY-21 PLACENTAS - HISTOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL FINDINGS USING PROLIFERATING CELL NUCLEAR ANTIGEN", Fetal diagnosis and therapy, 12(4), 1997, pp. 210-215

Abstract

Objective: The cause of growth retardation in trisomy 21 and other autosomal trisomies is not known, but may be the result of defective cell proliferation, slowing of the cell cycle, or placental structural abnormalities. Abnormalities of the fetal cell cycle may be reflected inplacental growth and can be detected using proliferating cell nuclearantigen (PCNA). Methods: Twelve second-trimester and six third-trimester trisomy 21 placentas were examined histopathologically and stainedimmunohistochemically using antibodies to PCNA. Normal age-matched placentas were used as controls. Results: The second-trimester trisomy 21 placentas all exhibited many large irregular hypovascular villi. Thethird-trimester trisomy 21 placentas showed two patterns: (i) many large, irregular hypovascular villi, and (ii) relatively normal-appearing villi with only a few abnormal villi and focal hypervascularity, PCNA staining was significantly greater in second-trimester placentas when compared to third-trimester placentas for both trisomy 21 and controls. There was no significant difference in PCNA staining in trisomy 21placentas when compared to the normal age-matched controls, Conclusions: PCNA staining indicates no significant differences in proliferation between normal and trisomy 21 placentas, Trisomy 21 placentas show villus abnormalities, including hypovascularity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 05:56:40