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Titolo:
ACCURATE METHOD TO STUDY STATIC VOLUME-PRESSURE RELATIONSHIPS IN SMALL FETAL AND NEONATAL ANIMALS
Autore:
SUEN HC; LOSTY PD; DONAHOE PK; SCHNITZER JJ;
Indirizzi:
MASSACHUSETTS GEN HOSP,PEDIAT SURG SERV,32 FRUIT ST BOSTON MA 02114 MASSACHUSETTS GEN HOSP,PEDIAT SURG SERV BOSTON MA 02114 MASSACHUSETTS GEN HOSP,PEDIAT SURG RES LABS,GEN THORAC SURG UNIT BOSTON MA 02114 HARVARD UNIV,SCH MED,DEPT SURG BOSTON MA 02114
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 77, anno: 1994,
pagine: 1036 - 1043
SICI:
8750-7587(1994)77:2<1036:AMTSSV>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY SURFACTANT; NEWBORN MAMMALS; LUNG;
Keywords:
FETAL RATS; NEONATAL RATS; RESPIRATORY SYSTEM COMPLIANCE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
H.C. Suen et al., "ACCURATE METHOD TO STUDY STATIC VOLUME-PRESSURE RELATIONSHIPS IN SMALL FETAL AND NEONATAL ANIMALS", Journal of applied physiology, 77(2), 1994, pp. 1036-1043

Abstract

We designed an accurate method to study respiratory static volume-pressure relationships in small fetal and neonatal animals on the basis of Archimedes' principle. Our method eliminates the error caused by thecompressibility of air (Boyle's law) and is sensitive to a volume change of as little as 1 mu l. Fetal and neonatal rats during the period of rapid lung development from clay 19.5 of gestation (term = day 22) to day 3.5 postnatum were studied. The absolute lung volume at a transrespiratory pressure of 30-40 cmH(2)O increased 28-fold from 0.036 +/-0.006 (SE) to 0.994 +/- 0.042 mi, the volume per gram of lung increased 14-fold from 0.39 +/- 0.07 to 5.59 +/- 0.66 ml/g, compliance increased 12-fold from 2.3 +/- 0.4 to 27.3 +/- 2.7 mu l/cmH(2)O, and specific compliance increased B-fold from 24.9 +/- 4.5 to 152.3 +/- 22.8 mu l.cmH(2)O(-1).g lung(-1). This technique, which allowed us to compare changes during late gestation and the early neonatal period in small rodents, can be used to monitor and evaluate pulmonary functional changes after in utero pharmacological therapies in experimentally induced abnormalities such as pulmonary hypoplasia, surfactant deficiency, and congenital diaphragmatic hernia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:23:08