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Titolo:
GRADIENT IN THE DURATION OF THE G1 PHASE IN THE MURINE NEOCORTICAL PROLIFERATIVE EPITHELIUM
Autore:
MIYAMA S; TAKAHASHI T; NOWAKOWSKI RS; CAVINESS VS;
Indirizzi:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,25 FRUIT ST BOSTON MA 02114 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL BOSTON MA 02114 KEIO UNIV,SCH MED,DEPT PEDIAT TOKYO 160 JAPAN UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL PISCATAWAY NJ 08854
Titolo Testata:
Cerebral cortex
fascicolo: 7, volume: 7, anno: 1997,
pagine: 678 - 689
SICI:
1047-3211(1997)7:7<678:GITDOT>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING CEREBRAL-CORTEX; CELL-CYCLE; VISUAL-CORTEX; MOUSE; PATTERNS; ORGANIZATION; DISPERSION; WALL; HISTOGENESIS; FOREBRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
S. Miyama et al., "GRADIENT IN THE DURATION OF THE G1 PHASE IN THE MURINE NEOCORTICAL PROLIFERATIVE EPITHELIUM", Cerebral cortex, 7(7), 1997, pp. 678-689

Abstract

Neuronogenesis in the neocortical pseudostratified ventricular epithelium (PVE) is initiated rostrolaterally acid progresses caudo-mediallyas development progresses. Here we have measured the cytokinetic parameters and the fractional neuronal output parameter, a, of laterally located early-maturing regions over the principal embryonic days (E12-E15) of neocortical neuronogenesis in the mouse. These measures are compared with ones previously made of a medial, late-maturing portion of fire PVE. Laterally, as medially, the duration of the neuronogenetic interval is 6 days and comprises 11 integer cell cycles. Also, in both lateral acid medial areas the length of G1 phase (T-G1) increases nearly 4-fold and is the only cell cycle parameter to change, a progressesessentially identically laterally and medially with respect to the succession of integer cell cycles. Most importantly, from E12 to E13 there is a steeply declining lateral to medial gradient in T-G1. The gradient is due both to the lateral to medial graded stage of neuronogenesis and to the stepwise increase in T-G1 with each integer cycle duringthe neuronogenetic interval. To our knowledge this gradient in T-G1 of the cerebral PVE is the first cell biological gradient to be demonstrated experimentally in such an extensive proliferative epithelial sheet. We suggest that this gradient in T-G1 is the cellular mechanism for positionally encoding a protomap of the neocortex within the PVE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 04:13:38