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Titolo:
MODULATION OF RESPIRATORY RHYTHM BY ALPHA(2)-ADRENOCEPTORS IN AWAKE AND ANESTHETIZED GOATS
Autore:
HEDRICK MS; RYAN ML; PIZARRO J; BISGARD GE;
Indirizzi:
UNIV WISCONSIN,SCH VET MED,DEPT COMPARAT BIOSCI,2015 LINDEN DR W MADISON WI 53706 UNIV WISCONSIN,SCH VET MED,DEPT COMPARAT BIOSCI MADISON WI 53706
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 77, anno: 1994,
pagine: 742 - 750
SICI:
8750-7587(1994)77:2<742:MORRBA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS CLONIDINE; VENTROLATERAL MEDULLA; BINDING-SITES; VENTILATION; ALPHA-2-ADRENOCEPTORS; DEXMEDETOMIDINE; RECEPTORS; NEURONS; ANALOGS; NUCLEUS;
Keywords:
CLONIDINE; GUANABENZ; SKF-86466; APNEA; PHRENIC NERVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Hedrick et al., "MODULATION OF RESPIRATORY RHYTHM BY ALPHA(2)-ADRENOCEPTORS IN AWAKE AND ANESTHETIZED GOATS", Journal of applied physiology, 77(2), 1994, pp. 742-750

Abstract

The purpose of this study was to examine the effects of alpha(2)-adrenoceptor agonists in the control of breathing with goats that were either awake (n = 7) or anesthetized and artificially ventilated (n = 11). Awake goats infused intravenously with either of the alpha(2)-agonists clonidine (1.0-6.0 mu g/kg) or guanabenz (15.0-63.0 mu g/kg) exhibited two distinct ventilatory patterns. One pattern was characterized by tachypnea in which respiratory frequency and minute ventilation increased to similar to 50% above control values. A second ventilatory pattern consisted of slow breathing with reductions of respiratory frequency and minute ventilation and highly variable expiratory duration intervals. These two patterns were unaffected by bilateral carotid body denervation. In anesthetized goats, alpha(2)-agonists also caused an arrhythmia in phrenic nerve activity that was similar to the slow breathing pattern seen in awake goats. Respiratory disturbances were abolished by the selective cu,-receptor antagonist SKF-86466 (100-500 mu g/kg), indicating that the effects are mediated by alpha-receptors. The results suggest that stimulation of alpha(2)-adrenoceptors generally hasan inhibitory effect on breathing in goats. The disruption of ventilation with clonidine or guanabenz suggests that alpha(2)-adrenoceptors may play an important role in the control of central respiratory rhythm.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:46:37