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Titolo:
A MOLECULAR MODELING ANALYSIS OF THE BINDING INTERACTIONS BETWEEN THEOKADAIC ACID CLASS OF NATURAL PRODUCT INHIBITORS AND THE SER-THR PHOSPHATASES, PP1 AND PP2A
Autore:
GAUSS CM; SHEPPECK JE; NAIRN AC; CHAMBERLIN R;
Indirizzi:
UNIV CALIF IRVINE,DEPT CHEM IRVINE CA 92697 ROCKEFELLER UNIV NEW YORK NY 10021
Titolo Testata:
Bioorganic & medicinal chemistry
fascicolo: 9, volume: 5, anno: 1997,
pagine: 1751 - 1773
SICI:
0968-0896(1997)5:9<1751:AMMAOT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN PHOSPHATASE-1; 3-DIMENSIONAL STRUCTURE; CATALYTIC SUBUNIT; TAUTOMYCIN; DEPHOSPHORYLATION; SPECIFICITY; DERIVATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Gauss et al., "A MOLECULAR MODELING ANALYSIS OF THE BINDING INTERACTIONS BETWEEN THEOKADAIC ACID CLASS OF NATURAL PRODUCT INHIBITORS AND THE SER-THR PHOSPHATASES, PP1 AND PP2A", Bioorganic & medicinal chemistry, 5(9), 1997, pp. 1751-1773

Abstract

We have proposed computer-generated models of the catalytic subunits of the serine-threonine protein phosphatases PP1 and PP2A complexed with their endogenous substrate phospho-DARPP-32, and several known naturally occurring inhibitors. This study is part of an overall effort toelucidate the signal transduction pathways in which PP1 and PP2A may play an important role. (C) 1997 Published by Elsevier Science Ltd.

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Documento generato il 05/07/20 alle ore 22:08:02