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Titolo:
LIFE-SPAN OF CIRCULATING MEMBRANE CD4 INSERTED INTO THE PLASMA-MEMBRANES OF AUTOLOGOUS RED-BLOOD-CELLS OF HIV-INFECTED SUBJECTS
Autore:
HOLLINGER FB; MOUNEIMNE Y; LAHART C; TOSI PF; DIMITROV D; NICOLAU C;
Indirizzi:
BAYLOR COLL MED,DIV MOLEC VIROL,1 BAYLOR PLAZA HOUSTON TX 77030 VET AFFAIRS MED CTR,AIDS & HIV INFECT RES CTR HOUSTON TX 77030 HARVARD UNIV,SCH MED BOSTON MA 00000 CTR BLOOD,RES LAB BOSTON MA 00000
Titolo Testata:
Journal of acquired immune deficiency syndromes and human retrovirology
fascicolo: 2, volume: 9, anno: 1995,
pagine: 126 - 132
SICI:
1077-9450(1995)9:2<126:LOCMCI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ENVELOPE GLYCOPROTEIN GP120; RECOMBINANT SOLUBLE CD4; RECEPTOR; BINDING; REGION; SITE; RETROVIRUS; RESIDUES; EPITOPES;
Keywords:
ANTI-HIV-1 THERAPY; ANTIVIRAL TREATMENT; CLINICAL ISOLATES; HIV; HIV-1 TRANSMISSION; RECOMBINANT CD4;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
F.B. Hollinger et al., "LIFE-SPAN OF CIRCULATING MEMBRANE CD4 INSERTED INTO THE PLASMA-MEMBRANES OF AUTOLOGOUS RED-BLOOD-CELLS OF HIV-INFECTED SUBJECTS", Journal of acquired immune deficiency syndromes and human retrovirology, 9(2), 1995, pp. 126-132

Abstract

Membrane recombinant CD4 was electroinserted into the plasma membraneof red blood cells (RBCs) from four HIV patients. CD4 had been labeled with I-125 before electroinsertion. The RBCs-CD4-I-125 were labeled with Cr-51 and autotransfused to the donor patients. The hematologicalindexes and the P-50 value of the RBCs were not modified by the electroinsertion of CD4. The life span of the RBCs was not affected by electroinsertion of CD4 (t(1/2) similar to 30 days), whereas the exposed CD4 showed a kinetics of disappearance characterized by two half-life times: a short one (t(1/2) similar to 1 day) and a long one approximately equal to that of the RBCs. No side effects or anti-CD4 immune responses were observed in patients over a period of 28 days. The RBC-CD4 entity appears to be long-lived and has no adverse effect in HIV patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:54:07