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Titolo:
SUBENDOTHELIAL PROTEOGLYCAN SYNTHESIS AND TRANSFORMING-GROWTH-FACTOR-BETA DISTRIBUTION CORRELATE WITH SUSCEPTIBILITY TO ATHEROSCLEROSIS
Autore:
SCOTT L; KERR A; HAYDOCK D; MERRILEES M;
Indirizzi:
UNIV AUCKLAND,SCH MED,DEPT ANAT,PRIVATE BAG 92019 AUCKLAND NEW ZEALAND UNIV AUCKLAND,SCH MED,DEPT ANAT AUCKLAND NEW ZEALAND GREEN LANE HOSP,CARDIOTHORAC UNIT AUCKLAND 3 NEW ZEALAND
Titolo Testata:
Journal of vascular research
fascicolo: 5, volume: 34, anno: 1997,
pagine: 365 - 377
SICI:
1018-1172(1997)34:5<365:SPSAT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; INTERNAL MAMMARY ARTERY; CHONDROITIN SULFATE PROTEOGLYCAN; CHOLESTERYL ESTER ACCUMULATION; SAPHENOUS-VEIN; BYPASS GRAFT; THORACIC ARTERY; FED RABBITS; LESIONS; FACTOR-BETA-1;
Keywords:
PROTEOGLYCANS; TRANSFORMING GROWTH FACTOR-BETA; ATHEROSCLEROSIS; CORONARY BYPASS; CORONARY ARTERIES; SAPHENOUS VEIN; INTERNAL THORACIC ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
L. Scott et al., "SUBENDOTHELIAL PROTEOGLYCAN SYNTHESIS AND TRANSFORMING-GROWTH-FACTOR-BETA DISTRIBUTION CORRELATE WITH SUSCEPTIBILITY TO ATHEROSCLEROSIS", Journal of vascular research, 34(5), 1997, pp. 365-377

Abstract

Coronary bypass vessels, saphenous vein (SV) and internal thoracic artery (ITA), differ in susceptibility to atherosclerosis and medium-to long-term patency. Whereas most ITA remain patent (90% at 10 years), 20% of SV grafts fail in the first year and similar to 45% fail within 10 years. Reasons for these differences are not fully understood. Lossof SV patency may reflect early metabolic events, particularly increased proteoglycan (PG) synthesis which contributes to intimal volume and promotes atherogenesis through retention of atherogenic lipoproteins. We determined, in vitro, the PG metabolic activity of SV, ITA, and human coronary arteries through autoradiographic detection of incorporated [H-3]glucosamine. SV had significantly higher levels of PG synthesis than ITA, especially in the subendothelial zone and after time (7 days) in culture. Patterns of synthesis in coronary vessels were similar to SV with high levels of incorporation in the subendothelial zone of thickened intima (>100 mu m). Increased subendothelial labelling in SV was due to increased PG synthesis, not decreased degradation. ITA showed no propensity for upregulation of subendothelial PG synthesis. Immunohistochemistry showed TGF-beta(1) and TGF-beta(2) localised primarily to the subendothelial zone of SV and coronary arteries. With timein culture immunostaining increased in parallel with increased PG synthesis. Subendothelial TGF-beta(1) and TGF-beta(2) were absent in ITA. A panspecific TGF-beta neutralising antibody reduced subendothelial PG synthesis in SV and coronary arteries by 50 and 60%, respectively. These results support the idea that vessels susceptible to atherosclerosis show increased accumulation of subendothelial PG mediated by TGF-beta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 12:09:25