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Titolo:
EARLY CHANGES OF THE ARTERIAL CAROTID WALL IN UNCOMPLICATED PRIMARY HYPERTENSIVE PATIENTS - STUDY BY ULTRASOUND HIGH-RESOLUTION B-MODE IMAGING
Autore:
FERRARA LA; MANCINI M; CELENTANO A; GALDERISI M; IANNUZZI R; MAROTTA T; GAETA I;
Indirizzi:
UNIV NAPLES FEDERICO II,SCH MED,INST INTERNAL MED & METAB DIS,VIA S PANSINI 5 I-80131 NAPLES ITALY
Titolo Testata:
Arteriosclerosis and thrombosis
fascicolo: 8, volume: 14, anno: 1994,
pagine: 1290 - 1296
SICI:
1049-8834(1994)14:8<1290:ECOTAC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR RISK-FACTORS; CORONARY HEART-DISEASE; BLOOD-PRESSURE; ATHEROSCLEROSIS; PREVALENCE; TRIAL; QUANTITATION; ASSOCIATIONS; MORBIDITY;
Keywords:
ARTERIAL HYPERTENSION; CAROTID WALL THICKNESS; ECHOCARDIOGRAPHY; ULTRASOUND IMAGING; LEFT VENTRICULAR HYPERTROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Ferrara et al., "EARLY CHANGES OF THE ARTERIAL CAROTID WALL IN UNCOMPLICATED PRIMARY HYPERTENSIVE PATIENTS - STUDY BY ULTRASOUND HIGH-RESOLUTION B-MODE IMAGING", Arteriosclerosis and thrombosis, 14(8), 1994, pp. 1290-1296

Abstract

Arterial hypertension is frequently responsible for arteriosclerotic damage in the carotid region. Nevertheless, there is as yet no generalagreement that hypertension is correlated with lesions detected by noninvasive means in the carotid arteries. We studied, by noninvasive echotomographic technique, 70 uncomplicated primary hypertensive individuals without clinically evident end-organ complications and 30 normotensive matched control subjects to detect early lesions of carotid arteries. The presence of other cardiovascular risk factors was assessed, and heart structure and function were studied by echocardiography. Although hypertensive individuals were comparable to control subjects forother risk factors, they showed a marked increase in the thickness ofthe intimal-medial complex of the carotid wall (0.71+/-0.4 versus 0.56+/-0.2 mm, P<.001 in the right carotid and 0.83+/-0.3 versus 0.58+/-0.2, P<.003 in the left), in left ventricular mass (203+/-52 versus 176/-37 g, P<.05), and in the prevalence of definite plaques of the carotid wall, both monolaterally and bilaterally (P<.003 by chi(2) test). Among the different factors contributing to the increase in thickness of the carotid artery wall, standing blood pressure, serum triglycerides, and age were found to be the best predictors (they accounted for about 16% of the variability, P<.005). These results indicate that carotid arteries of hypertensive individuals undergo degenerative changes,just as shown for hypercholesterolemic and diabetic patients in otherstudies. This supports the use of B-mode ultrasound imaging to detectearly involvement of the carotid region before the appearance of any end-organ damage of hypertension. Moreover, this finding sheds new light on the relationship between arterial wall damage and insulin resistance, since all the main contributors to intimal-medial thickening areparticularly altered in the presence of hyperinsulinemia and increased insulin resistance.

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Documento generato il 03/12/20 alle ore 16:05:06