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Titolo:
MOLECULAR ASPECTS OF NEUROONCOLOGY
Autore:
SANTARIUS T; KIRSCH M; ROSSI ML; BLACK PM;
Indirizzi:
HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,NEUROSURG LABS BOSTON MA 02115 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,BRAIN TUMOR CTR BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT SURG,DANA FARBER CANC INST BOSTON MA 02115 TECH UNIV DRESDEN,CARL GUSTAV CARUS KLINIKUM,NEUROCHIRURG KLIN D-01307 DRESDEN GERMANY UNIV LIVERPOOL,WALTON CTR NEUROL & NEUROSURG LIVERPOOL L69 3BX MERSEYSIDE ENGLAND HARVARD UNIV,SCH MED,CHILDRENS HOSP BOSTON MA 02115
Titolo Testata:
Clinical neurology and neurosurgery
fascicolo: 3, volume: 99, anno: 1997,
pagine: 184 - 195
SICI:
0303-8467(1997)99:3<184:MAON>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; PROGRAMMED CELL-DEATH; FACTOR RECEPTOR GENE; NEUROFIBROMATOSIS TYPE-1 GENE; HUMAN-MALIGNANT ASTROCYTOMA; DOMINANT-NEGATIVE MUTANTS; CENTRAL-NERVOUS-SYSTEM; GROWTH-FACTOR PDGF; 17P ALLELIC LOSS; GLIOBLASTOMA-MULTIFORME;
Keywords:
MOLECULAR BIOLOGY; NERVOUS SYSTEM TUMORS; PATHOGENESIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
141
Recensione:
Indirizzi per estratti:
Citazione:
T. Santarius et al., "MOLECULAR ASPECTS OF NEUROONCOLOGY", Clinical neurology and neurosurgery, 99(3), 1997, pp. 184-195

Abstract

Detailed understanding of molecule events responsible for brain tumorgrowth is a prerequisite for the development of effective therapeuticmodalities leading to improved prognosis and cure. Advances in molecular biology in the past decades have revolutionized our understanding of cancer, including brain tumors. We have learned that abnormal proliferation, inability of the cells to die and their potential to modify their tissue environment result from accumulation of genetic aberrations. This article reviews genetic mechanisms implicated in their pathogenesis of nervous system tumors, such as inactivation of tumor suppressor and replication error genes, generation of abnormal growth factor loops, alterations of apoptotic pathways and angiogenesis. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:33:45