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Titolo:
NOVEL PERSISTENT ACTIVATION OF MUSCARINIC M-1 RECEPTORS BY XANOMELINE
Autore:
CHRISTOPOULOS A; ELFAKAHANY EE;
Indirizzi:
UNIV MINNESOTA,SCH MED,DIV NEUROSCI RES PSYCHIAT,MAYO MEM,BOX 392 MINNEAPOLIS MN 55455
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 334, anno: 1997,
pagine: 3 - 4
SICI:
0014-2999(1997)334:1<3:NPAOMM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Keywords:
XANOMELINE; MUSCARINIC RECEPTORS; ALZHEIMERS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
A. Christopoulos e E.E. Elfakahany, "NOVEL PERSISTENT ACTIVATION OF MUSCARINIC M-1 RECEPTORS BY XANOMELINE", European journal of pharmacology, 334(1), 1997, pp. 3-4

Abstract

The muscarinic agonists, xanomeline and carbachol, displayed similar intrinsic activities in stimulating neuronal nitric oxide synthase at muscarinic M-1, receptors in Chinese hamster ovary (CHO) cells, with xanomeline being more potent. Pre-incubation (I h) with I mu M xanomeline, followed by extensive washing, resulted in a significantly elevated basal response, which was absent on co-incubation with atropine. This phenomenon was not observed with carbachol. This is the first reportof a persistent, receptor-activating effect of a muscarinic agonist. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:07:19