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Titolo:
LYSIS OF HIV-1-INFECTED CELLS AND INHIBITION OF VIRAL REPLICATION BY UNIVERSAL RECEPTOR T-CELLS
Autore:
YANG OO; TRAN AC; KALAMS SA; JOHNSON RP; ROBERTS MR; WALKER BD;
Indirizzi:
MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,ROOM 5234,149 13TH ST CHARLESTOWN MA 02129 MASSACHUSETTS GEN HOSP,AIDS RES CTR CHARLESTOWN MA 02129 HARVARD UNIV,SCH MED CHARLESTOWN MA 02129 CELL GENESYS INC FOSTER CITY CA 94404
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 21, volume: 94, anno: 1997,
pagine: 11478 - 11483
SICI:
0027-8424(1997)94:21<11478:LOHCAI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; HEPATITIS-B VIRUS; LYMPHOCYTE ACTIVITY; HIV-1 INFECTION; INTRACELLULAR INACTIVATION; FINE SPECIFICITY; CTL; RESPONSES; PEPTIDE; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
O.O. Yang et al., "LYSIS OF HIV-1-INFECTED CELLS AND INHIBITION OF VIRAL REPLICATION BY UNIVERSAL RECEPTOR T-CELLS", Proceedings of the National Academy of Sciences of the United Statesof America, 94(21), 1997, pp. 11478-11483

Abstract

Increasing evidence suggests that HIV-1-specific cytotoxic T lymphocytes (CTLs) are a key host immune response to HIV-1 infection. Generation of CTL responses for prevention or therapy of HIV-1 infection has several intrinsic technical barriers such as antigen expression and presentation, the varying HLA restrictions between different individuals,and the potential for viral escape by sequence variation or surface molecule alteration on infected cells. A strategy to circumvent these limitations is the construction of a chimeric T cell receptor containing human CD4 or HIV-1-specific Ig sequences linked to the signaling domain of the T cell receptor zeta chain (universal T cell receptor). CD8(+) CTLs transduced with this universal receptor can then bind and lyse infected cells that express surface HIV-1 gp120. We evaluated the ability of universal-receptor-bearing CD8(+) cells from a seronegative donor to lyse acutely infected cells and inhibit HIV-1 replication in vitro. The kinetics of lysis and efficiency of inhibition were comparable to that of naturally occurring HIV-1-specific CTL clones isolated from infected individuals. Further study will be required to determine the utility of these cells as a therapeutic strategy in vivo.

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Documento generato il 05/12/20 alle ore 01:28:00