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Titolo:
BIOACTIVE AND NUCLEASE-RESISTANT L-DNA LIGAND OF VASOPRESSIN
Autore:
WILLIAMS KP; LIU XH; SCHUMACHER TNM; LIN HY; AUSIELLO DA; KIM PS; BARTEL DP;
Indirizzi:
MIT,WHITEHEAD INST BIOMED RES CAMBRIDGE MA 02142 MIT,WHITEHEAD INST BIOMED RES CAMBRIDGE MA 02142 MIT,DEPT BIOL CAMBRIDGE MA 02142 HOWARD HUGHES MED INST,CAMBRIDGE CTR 9 CAMBRIDGE MA 02142 MASSACHUSETTS GEN HOSP,DEPT MED,PROGRAM MEMBRANE BIOL,RENAL UNIT CHARLESTOWN MA 02129
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 21, volume: 94, anno: 1997,
pagine: 11285 - 11290
SICI:
0027-8424(1997)94:21<11285:BANLLO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 LABELED OLIGONUCLEOTIDES; CELL-LINE LLC-PK1; RECEPTOR TRANSITION; ALPHA-L; RNA; SELECTION; BINDING; OLIGODEOXYNUCLEOTIDES; PHOSPHOROTHIOATE; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
K.P. Williams et al., "BIOACTIVE AND NUCLEASE-RESISTANT L-DNA LIGAND OF VASOPRESSIN", Proceedings of the National Academy of Sciences of the United Statesof America, 94(21), 1997, pp. 11285-11290

Abstract

In vitro selection experiments have produced nucleic acid ligands (aptamers) that bind tightly and specifically to a great variety of target biomolecules, The utility of aptamers is often limited by their vulnerability to nucleases present in biological materials, One way to circumvent this problem is to select an aptamer that binds the enantiomerof the target, then synthesize the enantiomer of the aptamer as a nuclease-insensitive ligand of the normal target, We have so identified amirror-image single-stranded DNA that binds the peptide hormone vasopressin and have demonstrated its stability to nucleases and its bioactivity as a vasopressin antagonist in cell culture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:26:46