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Titolo:
CORRELATION BETWEEN ANTIRETROVIRAL RESISTANCE MUTATIONS, BIOLOGICAL PARAMETERS, AND CLINICAL EVOLUTION IN ZIDOVUDINE-TREATED PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1
Autore:
LERICHEGUERIN K; TRABAUD MA; COTTE L; BISSUEL F; DERUELLE E; ROUGIER P; TREPO C;
Indirizzi:
INSERM,U271,151 COURS ALBERT THOMAS F-69003 LYON FRANCE INSERM,U271 F-69003 LYON FRANCE HOP HOTEL DIEU,HEPATOGASTROENTEROL & AIDS UNIT F-69002 LYON FRANCE
Titolo Testata:
European journal of clinical microbiology & infectious diseases
fascicolo: 9, volume: 16, anno: 1997,
pagine: 660 - 668
SICI:
0934-9723(1997)16:9<660:CBARMB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; THERAPY; HIV; AZT; DISEASE; SENSITIVITY; PROGRESSION; AIDS; INDIVIDUALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
K. Lericheguerin et al., "CORRELATION BETWEEN ANTIRETROVIRAL RESISTANCE MUTATIONS, BIOLOGICAL PARAMETERS, AND CLINICAL EVOLUTION IN ZIDOVUDINE-TREATED PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1", European journal of clinical microbiology & infectious diseases, 16(9), 1997, pp. 660-668

Abstract

To evaluate the correlation between zidovudine (ZDV) resistance mutations of human immunodeficiency Virus type 1 (HIV-1), biological parameters, and clinical evolution, 111 HIV-1-infected patients treated withZDV were studied, Specific mutations at codons 70, 215, and 41 in theHIV-1 reverse transcriptase coding region conferring resistance to ZDV were detected using a selective polymerase chain reaction, The appearance of ZDV resistance mutations was significantly correlated with baseline clinical stage, CD4+ cell count, and viral load, but not with duration of ZDV therapy or p24 antigen level, In univariate analysis, results showed a prognostic role of mutations at codons 215 and 41 for clinical progression to the acquired immune deficiency syndrome (AIDS)or death, In multivariate analysis after controlling for viral load, CD4+ cell count, and clinical stage, the presence of the mutation at codon 215 (but not at codon 41) remained an independent predictor of subsequent clinical evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:06:32