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Titolo:
CHEMOKINE PRODUCTION BY HUMAN VASCULAR SMOOTH-MUSCLE CELLS - MODULATION BY IL-13
Autore:
JORDAN NJ; WATSON ML; WILLIAMS RJ; ROACH AG; YOSHIMURA T; WESTWICK J;
Indirizzi:
UNIV BATH,SCH PHARM & PHARMACOL,DEPT PHARMACOL,CLAVERTON DOWN BATH BA2 7AY AVON ENGLAND RHONE POULENC RORER,DAGENHAM RES CTR DAGENHAM RM10 7XS ESSEX ENGLAND NCI,FREDERICK CANC RES & DEV CTR FREDERICK MD 21702
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 122, anno: 1997,
pagine: 749 - 757
SICI:
0007-1188(1997)122:4<749:CPBHVS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCYTE CHEMOATTRACTANT PROTEIN-1; HUMAN T-LYMPHOCYTES; BLOOD MONONUCLEAR LEUKOCYTES; HUMAN ENDOTHELIAL-CELLS; LOW-DENSITY-LIPOPROTEIN; ADHESION MOLECULE-1; HUMAN KERATINOCYTES; RANTES CHEMOKINE; GENE-EXPRESSION; CYTOKINE RANTES;
Keywords:
CHEMOKINE; INTERLEUKIN (IL)-1-ALPHA; IL-8; IL-10; IL-13; TNF-ALPHA; RANTES; MCP-1; SMOOTH MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
N.J. Jordan et al., "CHEMOKINE PRODUCTION BY HUMAN VASCULAR SMOOTH-MUSCLE CELLS - MODULATION BY IL-13", British Journal of Pharmacology, 122(4), 1997, pp. 749-757

Abstract

1 The production of chemokines by vascular smooth muscle cells (SMC) is implicated in the pathogenesis of atherosclerosis, although the factors regulating chemokine production by these cells are incompletely characterized. 2 We describe the differential stimulation of interleukin-(IL)-8, monocyte chemoattractant protein (MCP)-1 and regulated on activation normal T-cell expressed and secreted (RANTES) synthesis following treatment of human vascular SMC with IL-1 alpha or tumour necrosis factor alpha (TNF alpha). Under basal conditions, cultured SMC release very low amounts of IL-8, MCP-1 and RANTES as assessed by specific ELISA. Concentration-response studies with IL-1 alpha or TNF alpha revealed that each stimulus induced a similar amount of MCP-1. In contrast approximately three fold more IL-8 was induced by IL-1 alpha than byTNF alpha whereas significant RANTES production was induced only by TNF alpha. These findings point to a divergence in the regulation of synthesis of the different chemokines in response to IL-1 alpha or TNF alpha stimulation. 3 The T-cell derived cytokines IL-10 and IL-13 were also found to have differential effects on chemokine production by SMC. IL-13, but not IL-IO, significantly enhanced IL-8 and MCP-1 release in response to IL-1 alpha or TNF alpha. This increase in chemokine release appeared to be accounted for by increased mRNA expression. 4 These findings provide support for the concept that smooth muscle cells can have an active role in a local immune response via the production ofchemokines which can be selectively modulated by T-cell derived cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:03:26