Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE EFFECT OF THE SELECTIVE 5-HT1A AGONISTS ALNESPIRONE (S-20499) AND8-OH-DPAT ON EXTRACELLULAR 5-HYDROXYTRYPTAMINE IN DIFFERENT REGIONS OF RAT-BRAIN
Autore:
CASANOVAS JM; LESOURD M; ARTIGAS F;
Indirizzi:
CSIC,INST INVEST BIOMED BARCELONA,DEPT NEUROCHEM ES-08034 BARCELONA SPAIN CSIC,INST INVEST BIOMED BARCELONA,DEPT NEUROCHEM ES-08034 BARCELONA SPAIN INST RECH INT SERVIER F-92415 COURBEVOIE FRANCE
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 122, anno: 1997,
pagine: 733 - 741
SICI:
0007-1188(1997)122:4<733:TEOTS5>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAN RAPHE NUCLEI; IONOTROPIC GLUTAMATE RECEPTORS; DORSAL RAPHE; MIDBRAIN RAPHE; IN-VIVO; SEROTONIN RELEASE; ELECTROPHYSIOLOGICAL EVIDENCE; PARA-CHLOROAMPHETAMINE; ASCENDING PROJECTIONS; ADENYLYL-CYCLASE;
Keywords:
5-HYDROXYTRYPTAMINE (5-HT) RELEASE; 5-HT1A AGONISTS; ANTIDEPRESSANTS; DORSAL RAPHE NUCLEUS; DORSAL STRIATUM; HIPPOCAMPUS; MEDIAN RAPHE NUCLEUS; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Casanovas et al., "THE EFFECT OF THE SELECTIVE 5-HT1A AGONISTS ALNESPIRONE (S-20499) AND8-OH-DPAT ON EXTRACELLULAR 5-HYDROXYTRYPTAMINE IN DIFFERENT REGIONS OF RAT-BRAIN", British Journal of Pharmacology, 122(4), 1997, pp. 733-741

Abstract

1 We have examined the effects of the systemic administration of the selective 5-HT1A agonist alnespirone (S-20499) on in vivo 5-hydroxytryptamine (5-HT) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus). 2 Alnespirone (0.1-3 mg kg(-1), s.c.) dose-dependently reduced extracellular 5-HT in the six areas examined. In forebrain, the maximal reductions occurred in striatum and frontal cortex (maximal reduction to 23 and 29% of baseline, respectively). Those in dorsal and ventral hippocampus were more moderate (to ca 65% of baseline). In contrast, the decrease in 5-HT elicited in the median raphe nucleus was more marked than that in the dorsal raphe nucleus (to ca 30 and 60% of baseline, respectively). The selective 5-HT1A antagonist WAY-100635 (0.5 mg kg(-1), s.c.) prevented the decrease in 5-HT induced by alnespirone (0.3mg kg(-1), s.c.) in frontal cortex. 3 8-OH-DPAT (0.025, 0.1 and 0.3 mg kg(-1), s.c.) also reduced extracellular 5-HT in a regionally-selective manner (e.g., to 32% of baseline in striatum and to 69% in dorsal hippocampus at 0.1 mg kg(-1) s.c.). In midbrain, 8-OH-DPAT reduced thedialysate 5-HT slightly more in the median than in the dorsal raphe nucleus at all doses examined. 4 Doses of both compounds close to theirrespective ED50 values (0.3 mg kg(-1) alnespirone, 0.025 mg kg(-1) 8-OH-DPAT) reduced 5-HT to a comparable extent in all regions examined. However, the reductions attained at higher doses were more pronounced for 8-OH-DPAT. 5 These data show that the reduction of 5-HT release elicited by alnespirone and 8-OH-DPAT is more important in forebrain areas innervated by 5-hydroxytryptaminergic neurones of the dorsal raphe nucleus. This regional selectivity seems unlikely to be accounted for by differences in the sensitivity of 5H-T-1A autoreceptors controlling5-HT release, given the dissimilar effects of these two 5-HT1A agonists in regions rich in cell bodies and nerve terminals. This suggests the presence of complex mechanisms of control of 5-HT release by 5-HT1Areceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:41:33