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Titolo:
ORTHOGONAL ACCELERATION SINGLE-PASS TIME-OF-FLIGHT MASS-SPECTROMETRY FOR DETERMINATION OF THE EXACT MASSES OF PRODUCT IONS FORMED IN TANDEMMASS-SPECTROMETRY EXPERIMENTS
Autore:
KEOUGH T; LACEY MP; KETCHA MM; BATEMAN RH; GREEN MR;
Indirizzi:
PROCTER & GAMBLE CO,MIAMI VALLEY LABS,POB 538707 CINCINNATI OH 45243 MICROMASS LTD MANCHESTER M23 9LE LANCS ENGLAND
Titolo Testata:
Rapid communications in mass spectrometry
fascicolo: 15, volume: 11, anno: 1997,
pagine: 1702 - 1708
SICI:
0951-4198(1997)11:15<1702:OASTMF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
T. Keough et al., "ORTHOGONAL ACCELERATION SINGLE-PASS TIME-OF-FLIGHT MASS-SPECTROMETRY FOR DETERMINATION OF THE EXACT MASSES OF PRODUCT IONS FORMED IN TANDEMMASS-SPECTROMETRY EXPERIMENTS", Rapid communications in mass spectrometry, 11(15), 1997, pp. 1702-1708

Abstract

A hybrid magnetic sector/orthogonal acceleration single-pass time-of-flight (oaTOF) mass spectrometer has been used to measure the exact masses of product ions formed in high-and low-collision-energy MSMS experiments. Methods for both external and internal calibration of the mass scale have been evaluated, Mass accuracies of +/- 25 ppm are routinely achieved for product ions having masses greater than 200 Da, Best case mass accuracies of +/- 10 ppm have been obtained. Mass accuracy atlow mass is limited by the current speed of the time-to-digital converter (TDC), Experiments at reduced accelerating voltages suggest that doubling the TDC acquisition rate will increase low-mass accuracy six-fold. A number of applications of exact mass MSMS are presented, including: characterization of a side-reaction product formed in a combinatorial library synthesis, differentiation of isobaric residues in smallpeptides and a 'mimicked' MS3 measurement to confirm the identity of an unusual product ion previously observed in an ion trap MSMS experiment. (C) 1997 by John Whey & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:50:55