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Titolo:
HIGH INTRATUMORAL LEVEL OF CYTOKINES MEDIATES EFFICIENT REGRESSION OFA RAT HISTIOCYTOMA
Autore:
KHAR A; MURALIKRISHNA K; VARALAKSHMI C;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Clinical and experimental immunology
fascicolo: 1, volume: 110, anno: 1997,
pagine: 127 - 131
SICI:
0009-9104(1997)110:1<127:HILOCM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS IMMUNOLOGICAL REGRESSION; ACTIVATED KILLER-CELLS; AK-5 TUMOR; MONOCLONAL-ANTIBODIES; INTERLEUKIN-12; LYMPHOKINE; INTERFERON; CANCER; IMMUNOTHERAPY; MODULATION;
Keywords:
INTERLEUKINS; TUMOR REGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Khar et al., "HIGH INTRATUMORAL LEVEL OF CYTOKINES MEDIATES EFFICIENT REGRESSION OFA RAT HISTIOCYTOMA", Clinical and experimental immunology, 110(1), 1997, pp. 127-131

Abstract

We have studied the role of cytokines in the spontaneous regression of AK-5 histiocytoma in syngeneic rats. Animals in which the tumour regresses show high levels of cytokines in the serum compared with animals which succumb to the tumour, and levels of IL-2, IL-4, IL-12, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are significantly higher in tumour tissue of the former. Thus there is an association between rejection of the tumour and the levels of cytokines present in the tumour mass. Our results also suggest a predominantTh1-type of response in those rats that display early tumour rejection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:49:25