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Titolo:
NEW STRAINS OF INBRED SENCAR MICE WITH INCREASED SUSCEPTIBILITY TO INDUCTION OF PAPILLOMAS AND SQUAMOUS-CELL CARCINOMAS IN SKIN
Autore:
HENNINGS H; LOWRY DT; YUSPA SH; MOCK B; POTTER M;
Indirizzi:
NCI,CELLULAR CARCINOGENESIS & TUMOR PROMOT LAB,BLDG 37,ROOM 3B26 BETHESDA MD 20892 NCI,GENET LAB BETHESDA MD 20892
Titolo Testata:
Molecular carcinogenesis
fascicolo: 1, volume: 20, anno: 1997,
pagine: 143 - 150
SICI:
0899-1987(1997)20:1<143:NSOISM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALIGNANT CONVERSION; TUMOR PROMOTION; MOUSE SKIN; CHEMICAL CARCINOGENESIS; FEMALE SENCAR; CD-1 MICE; RESISTANT; LINES; DISSOCIATION; PROGRESSION;
Keywords:
SKIN TUMORS; INBRED SUSCEPTIBLE MICE; SQUAMOUS CELL CARCINOMA; PAPILLOMA; TUMOR INITIATION; TUMOR PROMOTION; SENCAR MICE; SUSCEPTIBILITY GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
H. Hennings et al., "NEW STRAINS OF INBRED SENCAR MICE WITH INCREASED SUSCEPTIBILITY TO INDUCTION OF PAPILLOMAS AND SQUAMOUS-CELL CARCINOMAS IN SKIN", Molecular carcinogenesis, 20(1), 1997, pp. 143-150

Abstract

To develop mouse strains useful for studies of susceptibility and resistance to the induction of skin tumors, three new inbred SENCAR strains were independently derived by random inbreeding of outbred SENCAR mice. Characterization of these mice for sensitivity to skin tumor development indicated that mice of all three strains displayed increased sensitivity to initiation by 7,12-dimethylbenz[a]anthracene (DMBA), urethane, or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and promotion by12-O-tetradecanoylphorbol-13-acetate (TPA). Promotion by mezerein as well as carcinogenesis by repeated treatment with DMBA or MNNG produced papillomas with a high frequency of conversion to squamous cell carcinomas (SCCs). Compared with outbred SENCAR mice, development of both squamous papillomas and carcinomas was increased at least two-fold by all protocols tested. The F-1 hybrid between SENCARA/Pt males and resistant BALB/cAnPt females was resistant to the induction of both papillomas and SCCs after initiation by 2 mu g of DMBA and promotion by 20 weekly applications of 2 mu g of TPA. Papillomas developed in all of the SENCARA/Pt mice, none of the BALB/cAnPt mice, and 12% of the F-1 progeny. Thus, at these doses of initiator and promoter, resistance was incompletely dominant in the F-1 hybrid. However, the responsiveness ofthe F-1 mice could be increased substantially by increasing the dose of the promoter. (C) 1997 Wiley-Liss, Inc.dagger

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Documento generato il 26/11/20 alle ore 08:22:17