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Titolo:
GENETIC ASSOCIATION STUDY BETWEEN PATHOLOGICAL GAMBLING AND A FUNCTIONAL DNA POLYMORPHISM AT THE D4 RECEPTOR GENE
Autore:
DECASTRO IP; IBANEZ A; TORRES P; SAIZRUIZ J; FERNANDEZPIQUERAS J;
Indirizzi:
UNIV AUTONOMA MADRID,FAC CIENCIAS,DEPT BIOL,LAB GENET MOL HUMANA E-28049 MADRID SPAIN UNIV AUTONOMA MADRID,FAC CIENCIAS,DEPT BIOL,LAB GENET MOL HUMANA E-28049 MADRID SPAIN UNIV ALCALA DE HENARES,HOSP RAMON Y CAJAL,SERV PSIQUIATRIA MADRID SPAIN
Titolo Testata:
Pharmacogenetics
fascicolo: 5, volume: 7, anno: 1997,
pagine: 345 - 348
SICI:
0960-314X(1997)7:5<345:GASBPG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOVELTY SEEKING; POPULATION; VARIANTS; ALCOHOLISM; DISORDER; GAMBLERS; LOCUS;
Keywords:
PATHOLOGICAL GAMBLING; DOPAMINE RECEPTORS; DRD2; DRD4; GENETIC ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
I.P. Decastro et al., "GENETIC ASSOCIATION STUDY BETWEEN PATHOLOGICAL GAMBLING AND A FUNCTIONAL DNA POLYMORPHISM AT THE D4 RECEPTOR GENE", Pharmacogenetics, 7(5), 1997, pp. 345-348

Abstract

A Spanish sample consisting of 68 Caucasian pathological gambling patients (47 males and 21 females) and 68 unaffected controls were screened by the molecular analysis of a functional DNA polymorphism in the locus for the D4 dopamine receptor gene, Our results are consistent with the existence of a significant association between genetic Variants at a DRD4 gene polymorphism and pathological gambling (chi(2) = 11.82;P = 0.037), This association seems to be sex-influenced, since there was no significant association when only males were considered (chi(2)= 9.45; P = 0.09), but there was a more significant association if weonly considered female subjects (chi(2) = 8.73; P = 0.033), Individuals with the longest allele (D7) were the most frequent in affected females (chi(2) = 4.50; P = 0.033). This work provides a new evidence of the implication of the dopaminergic reward pathways, now through the involvement of DRD4, in the aetiology of this impulsive disorder.

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Documento generato il 28/03/20 alle ore 21:49:52