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Titolo:
GLUTATHIONE DEFICIENCY DOES NOT ELEVATE SUSCEPTIBILITY OF BACTERIA TOTHE MUTAGENICITY OF CHLORINATED HUMIC ACIDS
Autore:
UBOM GA; CHIPMAN JK; HAYES MHB;
Indirizzi:
UNIV BIRMINGHAM,SCH BIOCHEM BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM,SCH BIOCHEM BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM,SCH CHEM BIRMINGHAM B15 2TT W MIDLANDS ENGLAND
Titolo Testata:
Human & experimental toxicology
fascicolo: 8, volume: 13, anno: 1994,
pagine: 558 - 562
SICI:
0960-3271(1994)13:8<558:GDDNES>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRINKING-WATER; MAMMALIAN-CELLS; BY-PRODUCTS; CHLORO-4-(DICHLOROMETHYL)-5-HYDROXY-2(5H)-FURANONE; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Ubom et al., "GLUTATHIONE DEFICIENCY DOES NOT ELEVATE SUSCEPTIBILITY OF BACTERIA TOTHE MUTAGENICITY OF CHLORINATED HUMIC ACIDS", Human & experimental toxicology, 13(8), 1994, pp. 558-562

Abstract

1 Rat liver 9,000 g supernatant protected against the mutagenic effect of chlorinated hydrophilic macromolecular humic acids (CHMA) in Salmonella typhimurium strain TA100. 2 Protection against mutagenicity of CHMA was mediated by glutathione and was partially dependent on glutathione S-transferase activity. 3 In contrast to the above findings, CHMA showed lower mutagenicity in Salmonella typhimurium and Escherichia coli strains of bacteria that are deficient in glutathione compared totheir mutagenicity in parental (glutathione-rich) bacterial strains. 4 Glutathione-deficient cells do not provide test systems with elevated sensitivity for the detection of mutagenic chlorinated humic substances.

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Documento generato il 03/12/20 alle ore 15:01:35