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Titolo:
ENDOTHELIUM-DEPENDENT VASODILATION IN THE BRACHIAL-ARTERY IS IMPAIREDIN SMOKERS - EFFECT OF VITAMIN-C
Autore:
MOTOYAMA T; KAWANO H; KUGIYAMA K; HIRASHIMA O; OHGUSHI M; YOSHIMURA M; OGAWA H; YASUE H;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DIV CARDIOL,HONJO 1-1-1 KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DIV CARDIOL KUMAMOTO 860 JAPAN
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 4, volume: 42, anno: 1997,
pagine: 1644 - 1650
SICI:
0363-6135(1997)42:4<1644:EVITBI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKING; NITRIC-OXIDE; LIPID-PEROXIDATION; CORONARY-ARTERIES; CAROTID-ARTERY; WALL THICKNESS; ADULTS; DYSFUNCTION; BLOOD; ATHEROSCLEROSIS;
Keywords:
OXIDATIVE STRESS; FLOW-MEDIATED VASODILATION; HIGH-RESOLUTION ULTRASOUND; ANTIOXIDANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T. Motoyama et al., "ENDOTHELIUM-DEPENDENT VASODILATION IN THE BRACHIAL-ARTERY IS IMPAIREDIN SMOKERS - EFFECT OF VITAMIN-C", American journal of physiology. Heart and circulatory physiology, 42(4), 1997, pp. 1644-1650

Abstract

Cigarette smoking has been shown to cause endothelial dysfunction. Toexamine the effects of vitamin C and cigarette smoking on endothelium-dependent vasodilation, we measured the lumen diameter and flow velocity of the brachial arteries at rest, during reactive hyperemia following transient arterial occlusion, and after sublingual nitroglycerin (0.3 mg) in smokers (n = 20) and nonsmokers (n = 20) with high-resolution ultrasound after infusion of saline or saline plus vitamin C (10 mg/min for 20 min). We also performed the same study in smokers (n = 15)before and 10 min after cigarette smoking. In addition, we measured the serum levels of vitamin C and the plasma levels of thiobarbituric acid-reactive substances (TEARS) as an index of lipid peroxidation. Thesmokers had lower vitamin C levels, higher TEARS levels, and showed impairment of from-dependent vasodilation (5.3 +/- 1.9 vs. 9.2 +/- 1.5%, P < 0.0001) compared with nonsmokers. Vitamin C administration improved the impairment of flow-dependent vasodilation (5.3 +/- 1.9 to 9.0 /- 3.2%, P < 0.001) and decreased TEARS in smokers but not in nonsmokers. Furthermore, cigarette smoking acutely worsened the impairment offlow-dependent vasodilation (5.4 +/- 1.8 to 1.5 +/- 1.3%, P < 0.01) and increased TEARS. We conclude that 1) endothelium-dependent vasodilation in the brachial arteries is impaired in smokers and this impairment is improved by vitamin C administration in association with a decrease in TEARS and 2) cigarette smoking produces acute impairment of endothelium-dependent vasodilation in smokers in association with an increase in TEARS.

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Documento generato il 27/11/20 alle ore 13:53:38