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Titolo:
GEMCITABINE - SAFETY PROFILE AND EFFICACY IN NONSMALL CELL LUNG-CANCER UNAFFECTED BY AGE
Autore:
MARTIN C; ARDIZZONI A; ROSSO R;
Indirizzi:
LILLY RES CTR LTD,ERL WOOD MANOR WINDLESHAM GU20 6PH SURREY ENGLAND
Titolo Testata:
Aging
fascicolo: 4, volume: 9, anno: 1997,
pagine: 297 - 303
SICI:
0394-9532(1997)9:4<297:G-SPAE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE-II TRIAL; 2',2'-DIFLUORODEOXYCYTIDINE; CHEMOTHERAPY;
Keywords:
AGED; CHEMOTHERAPY; DRUG THERAPY; NONSMALL CELL LUNG CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C. Martin et al., "GEMCITABINE - SAFETY PROFILE AND EFFICACY IN NONSMALL CELL LUNG-CANCER UNAFFECTED BY AGE", Aging, 9(4), 1997, pp. 297-303

Abstract

Gemcitabine, a novel anticancer agent, teas demonstrated to be well tolerated in both elderly and younger patients. Safety data were collected from 18 completed clinical studies (790 patients) in a variety of solid tumor types. All studies used a starting dose of 800-1250 mg/m(2) administered once a week for 3 weeks followed by a week of rest. Patients were initially divided using a cut-off age of 65 years, and subsequently using a cut-off age of 70 years. Gemcitabine was well tolerated by patients of all ages, with few clinically meaningful differencesbetween the age groups. Gemcitabine was also found to be as efficacious in older patients as in younger ones. Efficacy data was collected from four studies (329 evaluable patients)in nonsmall cell lung cancer with consistent response rates of 20%. When patients were divided intotwo groups, those aged below 70 years and those 70 years and above, the response rates were 19.0% (95% C.I., 14.6-23.4) and 25.0% (95% C.I., 10.0-40.0) respectively. In conclusion, elderly patients should benefit from gemcitabine treatment. (C) 1997, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 05:17:46