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Titolo:
GENETIC ASSOCIATION BETWEEN MONOAMINE-OXIDASE AND MANIC-DEPRESSIVE ILLNESS - COMPARISON OF RELATIVE RISK AND HAPLOTYPE RELATIVE RISK DATA
Autore:
PARSIAN A; TODD RD;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110
Titolo Testata:
American journal of medical genetics
fascicolo: 5, volume: 74, anno: 1997,
pagine: 475 - 479
SICI:
0148-7299(1997)74:5<475:GABMAM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR-AFFECTIVE-DISORDER; PLATELET MAO; A GENE; ALCOHOLISM; POLYMORPHISMS; SUBTYPES; ALLELES;
Keywords:
MANIC DEPRESSION; MONOAMINE OXIDASES; RELATIVE RISK; HAPLOTYPE RELATIVE RISK; POPULATION STRATIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Parsian e R.D. Todd, "GENETIC ASSOCIATION BETWEEN MONOAMINE-OXIDASE AND MANIC-DEPRESSIVE ILLNESS - COMPARISON OF RELATIVE RISK AND HAPLOTYPE RELATIVE RISK DATA", American journal of medical genetics, 74(5), 1997, pp. 475-479

Abstract

There have been several conflicting reports of association of monoamine oxidase (MAO) A gene polymorphisms and bipolar affective disorder, In order to determine the possible role of the MAO region in susceptibility to affective disorders in an independent sample, we have genotyped 83 probands of bipolar affective disorder families, 56 sets of parents of bipolar probands, and 84 normal controls for intronic simple sequence repeat polymorphisms of the MAO-A and MAO-B genes, For MAO-A there were no significant differences in allele frequencies between bipolar and normal control groups for both genders, However, for MAO-B there were significant differences between groups for both genders, In contrast, allele-wise haplotype relative risk analysis for the 56 bipolar proband-parent trios found no significant differences between transmitted and nontransmitted allele frequencies for MAO-A or B, These datado not support the association of MAO-A or B with bipolar affective disorder but do demonstrate that undetected population stratification can be an important source of bias in case-control studies, (C) 1997 Wiley-Liss, Inc.

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Documento generato il 03/07/20 alle ore 16:44:59