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Titolo:
CONTROL OF THE TOXR VIRULENCE REGULON IN VIBRIO-CHOLERAE BY ENVIRONMENTAL STIMULI
Autore:
SKORUPSKI K; TAYLOR RK;
Indirizzi:
DARTMOUTH COLL SCH MED,DEPT MICROBIOL HANOVER NH 03755 DARTMOUTH COLL SCH MED,DEPT MICROBIOL HANOVER NH 03755
Titolo Testata:
Molecular microbiology
fascicolo: 6, volume: 25, anno: 1997,
pagine: 1003 - 1009
SICI:
0950-382X(1997)25:6<1003:COTTVR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER-MEMBRANE PROTEIN; TCP GENE-CLUSTER; EL-TOR STRAINS; TRANSCRIPTIONAL ACTIVATORS; SIGNAL-TRANSDUCTION; COREGULATED-PILUS; ESCHERICHIA-COLI; REGULATORY GENE; ARAC FAMILY; PROMOTER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
K. Skorupski e R.K. Taylor, "CONTROL OF THE TOXR VIRULENCE REGULON IN VIBRIO-CHOLERAE BY ENVIRONMENTAL STIMULI", Molecular microbiology, 25(6), 1997, pp. 1003-1009

Abstract

Many bacterial pathogens regulate the expression of virulence genes in a co-ordinate manner in response to changes in the environment, For example, the human pathogen, Vibrio cholerae, possesses a virulence regulon composed of over 20 genes involved in colonization, toxin production and bacterial survival within the host, which are co-ordinately regulated by external stimuli, such as temperature, pH and osmolarity. Although the expression of the regulon is dependent upon the transcriptional activator ToxR, most of these genes are controlled by a second transcriptional activator, ToxT, which is itself positively regulated by ToxR. The mechanisms by which environmental stimuli influence the ToxR regulon are not yet understood, but ToxR-mediated control over theexpression of toxT clearly plays a role, The recent finding that the global regulator cAMP-CRP also influences the expression of the ToxR regulon under various environmental conditions raises new issues regarding the pathways and mechanisms by which this regulation is achieved and indicates that multiple overlapping systems are involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 01:55:28