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Titolo:
INCREASED CARBON-MONOXIDE IN EXHALED AIR OF ASTHMATIC-PATIENTS
Autore:
ZAYASU K; SEKIZAWA K; OKINAGA S; YAMAYA M; OHRUI T; SASAKI H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU,SEIRYO MACHI 1-1 SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU SENDAI MIYAGI 980 JAPAN
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 156, anno: 1997,
pagine: 1140 - 1143
SICI:
1073-449X(1997)156:4<1140:ICIEAO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; HEME OXYGENASE; SPUTUM; GLUCOCORTICOIDS; ACTIVATION; INDUCTION; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
K. Zayasu et al., "INCREASED CARBON-MONOXIDE IN EXHALED AIR OF ASTHMATIC-PATIENTS", American journal of respiratory and critical care medicine, 156(4), 1997, pp. 1140-1143

Abstract

Exhaled carbon monoxide (CO) concentrations were measured on a CO monitor by vital capacity maneuvers in asthmatic patients receiving or not receiving inhaled corticosteroids and in nonsmoking and smoking healthy control subjects. CO was detectable and measured reproducibly in the exhaled air of all subjects. The exhaled CO concentrations were higher in asthmatic patients not receiving inhaled corticosteroids (5.6 +/- 0.6 ppm, p < 0.001) and similar in asthmatic patients receiving inhaled corticosteroids (1.7 +/- 0.1 ppm) compared with those in nonsmoking healthy control subjects (1.5 +/- 0.1 ppm). Smoking healthy controlsubjects had the highest levels of exhaled CO concentration among thegroups (21.6 +/- 2.8 ppm, p < 0.001). To examine whether inhaling corticosteroids reduce exhaled CO concentration in a given asthmatic patient, 12 patients with symptomatic asthma who were being treated by inhaled beta(2)-agonists alone underwent measurements of exhaled CO concentration before and 4 wk after the initiation of inhaled corticosteroid treatment. All patients had reductions in exhaled CO concentration (p < 0.001) and eosinophil cell counts in sputum (p < 0.01) that were accompanied by an improvement in airway obstruction. Changes in exhaledCO concentration were significantly related to those in the eosinophil cell counts in sputum (p < 0.001). The present study shows an elevation of exhaled CO in asthmatic patients that decreases with corticosteroid therapy. Increases in the exhaled CO levels therefore may reflectinflammation in the asthmatic lung.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:49:59