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Titolo:
EXOGENOUS SURFACTANT AND PARTIAL LIQUID VENTILATION - PHYSIOLOGICAL AND PATHOLOGICAL EFFECTS
Autore:
MROZEK JD; SMITH KM; BING DR; MEYERS PA; SIMONTON SC; CONNETT JE; MAMMEL MC;
Indirizzi:
CHILDRENS HOSP ST PAUL,DEPT NEONATAL MED,345 N SMITH AVE,RM 2100 ST PAUL MN 55102 CHILDRENS HLTH CARE ST PAUL,INFANT PULM RES CTR ST PAUL MN 00000 UNIV MINNESOTA,DEPT PEDIAT MINNEAPOLIS MN 55455 UNIV MINNESOTA,DEPT BIOSTAT MINNEAPOLIS MN 55455
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 156, anno: 1997,
pagine: 1058 - 1065
SICI:
1073-449X(1997)156:4<1058:ESAPLV>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; HYALINE-MEMBRANE DISEASE; ACUTE LUNG INJURY; GAS-EXCHANGE; BRONCHOPULMONARY DYSPLASIA; MECHANICAL VENTILATION; SYNTHETIC SURFACTANT; PREMATURE-INFANTS; PERFLUOROCARBON; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Mrozek et al., "EXOGENOUS SURFACTANT AND PARTIAL LIQUID VENTILATION - PHYSIOLOGICAL AND PATHOLOGICAL EFFECTS", American journal of respiratory and critical care medicine, 156(4), 1997, pp. 1058-1065

Abstract

We compared the effects of surfactant and partial liquid ventilation (PLV), and the impact of administration order, on oxygenation, respiratory system compliance (Crs), hemodynamics, and lung pathology in an animal lung injury model. We studied four groups: surfactant alone (S; n = 8); partial liquid ventilation alone (PLV-only; n = 8); surfactantfollowed by partial liquid ventilation (S-PLV; n = 8); and partial liquid ventilation followed by surfactant (PLV-S; n = 8). Following treatments, all animals had improved oxygenation index (OI) and Crs. Animals in PLV groups showed continued improvement over 2 h (% change OI: PLV-S -83% versus S -47%, p < 0.05; % change Crs: S-PLV 73% versus S 13%, p < 0.05). We also saw administration-order effects: surfactant before PLV improved Crs (0.92 ml/cm H2O after surfactant versus 1.13 ml/cm H2O after PLV, p < 0.02) without changing OI, whereas surfactant after PLV did not change Crs and OI increased (5.01 after PLV versus 8.92after surfactant p < 0.03). Hemodynamics were not different between groups. Pathologic analysis demonstrated decreased lung injury in dependent lobes of all PLV-treated animals, and in all lobes of S-PLV animals, when compared with the lobes of the S animals (p < 0.05). We conclude that surfactant therapy in combination with PLV improved oxygenation, respiratory system mechanics, and lung pathology to a greater degree than surfactant therapy alone. Administration order affected initial physiologic response and ultimate pathology: surfactant given beforePLV produced the greatest improvements in pathologic outcomes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:14:27