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Titolo:
ENDOTHELIN-1 INCREASES RAT DISTAL TUBULE ACIDIFICATION IN-VIVO
Autore:
WESSON DE; DOLSON GM;
Indirizzi:
TEXAS TECH UNIV,HLTH SCI CTR,RENAL SECT,3601 4TH ST LUBBOCK TX 79430 TEXAS TECH UNIV,HLTH SCI CTR,DEPT INTERNAL MED LUBBOCK TX 79430 TEXAS TECH UNIV,HLTH SCI CTR,DEPT PHYSIOL LUBBOCK TX 79430 BAYLOR COLL MED,VET AFFAIRS MED CTR,DEPT INTERNAL MED HOUSTON TX 77030
Titolo Testata:
American journal of physiology. Renal, fluid and electrolyte physiology
fascicolo: 4, volume: 42, anno: 1997,
pagine: 586 - 594
SICI:
0363-6127(1997)42:4<586:EIRDTA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL BICARBONATE REABSORPTION; NEPHRON SEGMENTS; NA+/H+ EXCHANGE; PHOSPHOLIPASE-C; ATPASE ACTIVITY; CELLS; TRANSPORT; ALKALOSIS; SECRETION; RECEPTOR;
Keywords:
ACID; BICARBONATE; INDOMETHACIN; MICROPUNCTURE; PROSTACYCLIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Wesson e G.M. Dolson, "ENDOTHELIN-1 INCREASES RAT DISTAL TUBULE ACIDIFICATION IN-VIVO", American journal of physiology. Renal, fluid and electrolyte physiology, 42(4), 1997, pp. 586-594

Abstract

Because endothelin receptor inhibition blunts increased distal tubuleacidification induced by dietary acid, we examined whether endothelin-1 (ET-1) increases acidification of in vivo perfused distal tubules of anesthetized rats. ET-1 was infused intraaortically (1.4 pmol.kg(-1).min(-1)) into control animals and into those with increased distal tubule HCO3 secretion induced by drinking 80 mM NaHCO3 solution for 7-10days. ET-1 increased distal tubule acidification in both control and NaHCO3 animals. Increased acidification in control animals was mediated by increased distal tubule H+ secretion (23.7 +/- 2.2 vs. 18.7 +/- 1.7 pmol.kg(-1).min(-1), P < 0.05) with no changes in HCO3 secretion. By contrast, ET-1 increased distal tubule acidification in NaHCO3 animals predominantly by decreasing HCO3 secretion (-9.5 +/- 1.0 vs. -18.7 /- 1.8 pmol.mm(-1).min(-1), P < 0.001) with less influence on H+ secretion. When indomethacin was infused (83 mu g.kg(-1).min(-1)) to inhibit synthesis of prostacyclin, an agent previously shown to increase HCO3 secretion in the distal tubule, ET-1 increased distal tubule H+ secretion in both control (24.3 +/- 2.2 vs. 15.7 +/- 1.6 pmol.mm(-1).min(-1), P < 0.02) and NaHCO3 (20.0 +/- 2.0 vs. 13.6 +/- 1.4 pmol.mm(-1).min(-1), P < 0.05) without affecting HCO3 secretion. The data show thatET-1 increases distal tubule acidification in vivo and can do so by increasing H+ secretion and by decreasing HCO3 secretion when the latter is augmented by dietary NaHCO3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 13:55:59