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Titolo:
THE CYP2D6 EXTENSIVE METABOLIZER GENOTYPE IS ASSOCIATED WITH INCREASED RISK FOR BLADDER-CANCER
Autore:
ABDELRAHMAN SZ; ANWAR WA; ABDELAAL WE; GHONEIM MA; AU WW;
Indirizzi:
UNIV TEXAS,MED BRANCH,DEPT PREVENT MED & COMMUNITY HLTH GALVESTON TX 77555 UNIV TEXAS,MED BRANCH,DEPT PREVENT MED & COMMUNITY HLTH GALVESTON TX 77555 EIN SHAMS UNIV,DEPT COMMUNITY ENVIRONM & OCCUPAT MED CAIRO EGYPT NATL RES CTR,DEPT BASIC MED SCI CAIRO EGYPT CAIRO UNIV,FAC VET MED,DEPT BIOCHEM CAIRO EGYPT
Titolo Testata:
Cancer letters
fascicolo: 1, volume: 119, anno: 1997,
pagine: 115 - 122
SICI:
0304-3835(1997)119:1<115:TCEMGI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUNG-CANCER; POOR METABOLIZERS; GENETIC-POLYMORPHISM; DRUG-METABOLISM; DEBRISOQUINE; MUTATIONS; SUSCEPTIBILITY; EXPRESSION; CARCINOMA; OXIDATION;
Keywords:
GENETIC POLYMORPHISM; CYP2D6; BLADDER CANCER; BILHARZIA; CYTOCHROME P-450 SCHISTOSOMA; GENETIC SUSCEPTIBILITY; PCR; RFLP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
S.Z. Abdelrahman et al., "THE CYP2D6 EXTENSIVE METABOLIZER GENOTYPE IS ASSOCIATED WITH INCREASED RISK FOR BLADDER-CANCER", Cancer letters, 119(1), 1997, pp. 115-122

Abstract

Inheritance of certain polymorphic metabolizing genes is associated with the development of a number of environmental cancers and may also influence the clinicopathological tumor outcome. We have investigated the association between the inheritance of the polymorphic cytochrome P-450 2D6 (CYP2D6) gene and the development of transitional and squamous cell carcinomas (TCC and SCC) of the bladder in 37 Egyptian cancer patients and 27 matched controls. Genotypic analysis using the polymerase chain reaction (PCR) and the restriction fragment length polymorphism (RFLP) assays revealed that the CYP2D6 extensive metabolizer genotype (CYP2D61A) is over represented in bladder cancer patients compared to controls (79 versus 44%, respectively) and is significantly associated with increased risk for bladder cancer (odds ratio (OR) = 4.5, 95% confidence limit (CL) = 1.3-15.7, P = 0.006). Our results also indicate that individuals who have inherited this genotype are more likelyto develop TCC (OR = 5.9, 95% CL = 1.4-27.9, P = 0.006) rather than SCC (OR = 3.1, 95% CL = 0.7-15.9; P = 0.09). When the relative risk associated with this genotype was estimated among subjects who were smokers or schistosoma infected, the same tendency towards the development of TCC was observed. These data suggest that the predisposing CYP2D6 gene may not only increase the risk for bladder cancer among Egyptians,but may also influence the clinicopathological tumor outcome. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 14:08:40