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Titolo:
EFFECT OF OXIDIZED LOW-DENSITY-LIPOPROTEIN ON THROMBOMODULIN EXPRESSION BY THP-1 CELLS
Autore:
OIDA K; TOHDA G; ISHII H; HORIE S; KOHNO M; OKADA E; SUZUKI J; NAKAI T; MIYAMORI I;
Indirizzi:
FUKUI MED UNIV,DEPT INTERNAL MED 3 MATSUOKA FUKUI 91011 JAPAN SHOWA COLL PHARMACEUT SCI,DEPT PUBL HLTH MACHIDA TOKYO 194 JAPAN TEIKYO UNIV,FAC PHARMACEUT SCI,DEPT CLIN BIOCHEM KANAGAWA JAPAN
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 4, volume: 78, anno: 1997,
pagine: 1228 - 1233
SICI:
0340-6245(1997)78:4<1228:EOOLOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROMYELOCYTIC LEUKEMIA-CELLS; HUMAN ENDOTHELIAL-CELLS; TUMOR-NECROSIS-FACTOR; ACTIVATED PROTEIN-C; SCAVENGER RECEPTOR; NATURAL ANTICOAGULANT; PHORBOL DIESTER; FACTOR-V; INDUCTION; LINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
K. Oida et al., "EFFECT OF OXIDIZED LOW-DENSITY-LIPOPROTEIN ON THROMBOMODULIN EXPRESSION BY THP-1 CELLS", Thrombosis and haemostasis, 78(4), 1997, pp. 1228-1233

Abstract

We have investigated the effects of oxidized low density lipoproteins(oxidized LDL) on the expression of TM by THP-1 monocytic cells. TM antigen levels and its cofactor activity for thrombin-dependent proteinC activation were increased by oxidized LDL and accompanied by an increase in TM mRNA levels. Incubation of THP-1 cells with 300 mu g/ml oxidized LDL for 24 h resulted in an 80% increase of cellular TM antigenlevels. Native LDL and acetylated LDL did not affect the TM expression by these cells. The resultant aqueous phase after extraction of oxidized LDL by chloroform/methanol increased the TM antigen levels as well as oxidized LDL. Phorbol 12-myristate 13-acetate (PMA) also increased the TM antigen level 2.1 times the control and was accompanied by the adhesion of cells to plastic dishes and increasing macrophage cell surface antigen CD14 levels. In contrast, oxidized LDL did not induce differentiation to the macrophage. The present results indicate that oxidized LDL increases cellular TM antigen without cellular differentiation and that up-regulation of TM by oxidized LDL in monocytes may havesome implication in atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:59:25