Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EPIDEMIOLOGIC-STUDY OF THE GENETICS AND ENVIRONMENT OF ASTHMA, BRONCHIAL HYPERRESPONSIVENESS, AND ATOPY - PHENOTYPE ISSUES
Autore:
KAUFFMANN F; DIZIER MH; PIN I; PATY E; GORMAND F; VERVLOET D; BOUSQUET J; NEUKIRCH F; ANNESI I; ORYSZCZYN MP; LATHROP M; DEMENAIS F; LOCKHART A; FEINGOLD J;
Indirizzi:
INSERM,U169,EPIDEMIOL RES UNIT,16 AVE PV COUTURIER F-94807 VILLEJUIF FRANCE INSERM U155 PARIS FRANCE CHU GRENOBLE,HOP NECKER ENFANTS MALAD PARIS FRANCE HOP ST MARGUERITE,HOP LYON SUD MARSEILLE FRANCE HOP ARNAUD DE VILLENEUVE MONTPELLIER FRANCE INSERM U408 PARIS FRANCE WELLCOME TRUST CTR HUMAN GENET OXFORD ENGLAND INSERM U358 PARIS FRANCE HOP COCHIN F-75674 PARIS FRANCE
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 4, volume: 156, anno: 1997, supplemento:, S
pagine: 123 - 129
SICI:
1073-449X(1997)156:4<123:EOTGAE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-TEST REACTIVITY; SERUM IGE LEVELS; MAJOR GENE; ALLERGENS; LINKAGE; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
F. Kauffmann et al., "EPIDEMIOLOGIC-STUDY OF THE GENETICS AND ENVIRONMENT OF ASTHMA, BRONCHIAL HYPERRESPONSIVENESS, AND ATOPY - PHENOTYPE ISSUES", American journal of respiratory and critical care medicine, 156(4), 1997, pp. 123-129

Abstract

The Epidemiological Study of the Genetics and Environment of Asthma (EG EA) combined a case-control study and a family study. The total sample of 1,854 consisted of 348 patients with asthma selected through chest clinics and 416 control subjects and nuclear families ascertained through the cases. The protocol included standardized questionnaires, bronchial responsiveness, allergen skin-prick tests according to international protocols, total serum immunoglobulin E (IgE) level measurements, and blood eosinophilia. Criteria used to select subjects with asthma and determine asthma status of relatives for affected sibling pairlinkage analysis are described. Based on figures from the 348 asthma cases of the EGEA study, issues relative to the definition of severe asthma and intermediate phenotypes such as bronchial responsiveness andallergic markers are discussed. Given the phenotypic heterogeneity involved, relevant phenotypes that may lead to the detection of genetic factors will depend on the hypothesis tested. Standardization of primary data and subphenotypes is a prerequisite for pooling data, which will be needed in the future to better understand the genetics and environmental factors of asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:12:48