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Titolo:
MANAGING THE BEHAVIORAL AND PSYCHOLOGICAL SIGNS AND SYMPTOMS OF DEMENTIA
Autore:
FINKEL SI;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,303 E OHIO ST 550CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,ALZHEIMERS DIS CTR CHICAGO IL 60611
Titolo Testata:
International clinical psychopharmacology
, volume: 12, anno: 1997, supplemento:, 4
pagine: 25 - 28
SICI:
0268-1315(1997)12:<25:MTBAPS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NURSING-HOME PATIENTS; ALZHEIMERS-DISEASE; DISORDERS; HALOPERIDOL; AGITATION; LOXAPINE; EFFICACY; TRIAL; CARE;
Keywords:
DEMENTIA; NEUROLEPTICS; RISPERIDONE; BEHAVIORAL DISTURBANCE; PSYCHOTIC SYMPTOMS; EXTRAPYRAMIDAL SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
S.I. Finkel, "MANAGING THE BEHAVIORAL AND PSYCHOLOGICAL SIGNS AND SYMPTOMS OF DEMENTIA", International clinical psychopharmacology, 12, 1997, pp. 25-28

Abstract

As the world's population ages, increasing numbers of patients with dementia can be expected, the signs and symptoms of which can be extremely disruptive. In particular, behavioral and psychological signs and symptoms of dementia reduce the quality of life of carers (usually family members) and increase the cost of care. Conventional neuroleptics have been used for many years in the management of disturbed and disruptive demented patients, although there are few well-controlled clinical trials demonstrating their efficacy. The use of the low-potency neuroleptics is associated with orthostatic hypotension, cardiac toxicity, anticholinergic side effects and daytime sedation. The high-potency neuroleptics tend to cause extrapyramidal side effects and akathisia. Clozapine although less likely to cause extrapyramidal symptoms than conventional neuroleptics, can cause orthostatic hypotension and requires continual blood monitoring. Early-phase open trials suggest that risperidone is efficacious in patients with behavioral and psychologicalsigns and symptoms of dementia and that it has a low side-effects profile. Further trials are needed to confirm this, but it is likely thatthe newer antipsychotics, as typified by risperidone, will lead to safer and more effective management of patients with the disruptive and costly behavioral and psychological signs and symptoms of dementia. Non-pharmacologic interventions may also provide benefit, though controls are rare.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:45:06