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Titolo:
INCIDENCE OF AND RISK-FACTORS FOR ATRIAL-FIBRILLATION IN OLDER ADULTS
Autore:
PSATY BM; MANOLIO TA; KULLER LH; KRONMAL RA; CUSHMAN M; FRIED LP; WHITE R; FURBERG CD; RAUTAHARJU PM;
Indirizzi:
CARDIOVASC HLTH STUDY COORDINATING CTR,CENTURY SQ,SUITE 2105,1501 4THAVE SEATTLE WA 98101 UNIV WASHINGTON,DEPT MED,CARDIOVASC HLTH RES UNIT SEATTLE WA 00000 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL PITTSBURGH PA 15260 UNIV VERMONT,DEPT MED BURLINGTON VT 00000 JOHNS HOPKINS UNIV,DEPT MED BALTIMORE MD 00000 JOHNS HOPKINS UNIV,DEPT EPIDEMIOL BALTIMORE MD 00000 UNIV CALIF DAVIS,DEPT MED DAVIS CA 00000 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103
Titolo Testata:
Circulation
fascicolo: 7, volume: 96, anno: 1997,
pagine: 2455 - 2461
SICI:
0009-7322(1997)96:7<2455:IOARFA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR HEALTH; HEART-DISEASE; DRUG-THERAPY; STROKE; POPULATION; PREVALENCE; FEATURES;
Keywords:
FIBRILLATION; ATRIAL FLUTTER; EPIDEMIOLOGY; FOLLOW-UP STUDIES; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
B.M. Psaty et al., "INCIDENCE OF AND RISK-FACTORS FOR ATRIAL-FIBRILLATION IN OLDER ADULTS", Circulation, 96(7), 1997, pp. 2455-2461

Abstract

Background This study aimed to describe the incidence of atrial fibrillation (AF) among older adults during 3 years of follow-up. Methods and Results In this cohort study, 5201 adults greater than or equal to 65 years old were examined annually on four occasions between June 1989 and May 1993. Ar baseline, participants answered questionnaires and underwent a detailed examination that included carotid ultrasound, pulmonary function tests, EGG, and echocardiography. Subjects with a pacemaker or AF at baseline (n = 357) were excluded. New cases of AF were identified from three sources: (1) annual self-reports, (2) annual ECGs, and (3) hospital discharge diagnoses. Cox proportional-hazards models were used to assess baseline risk factors as predictors of incidentAF. Among 4844 participants, 304 developed a first episode of AF during an average follow-up of 3.28 years, for an incidence of 19.2 per 1000 person-years. The onset was strongly associated with age, male sex,and the presence of clinical cardiovascular disease. For men 65 to 74and 75 to 84 years old, the incidences were 17.6 and 42.7, respectively, and for women, 10.1 and 21.6 events per 1000 person-years. In stepwise models, the use of diuretics, a history of valvular heart disease, coronary disease, advancing age, higher levels of systolic blood pressure, height, glucose, and left atrial size were all associated with an increased risk of AF. The use of beta-blockers and high levels of alcohol use, cholesterol, and forced expiratory volume in 1 second wereassociated with a reduced risk of AF. Conclusions The incidence of AFin older adults may be higher than estimated by previous population studies. Left atrial size appears to be an important risk factor, and the control of blood pressure and glucose may be important in preventing the development of AF.

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Documento generato il 05/12/20 alle ore 01:38:29