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Titolo:
ZWITTERIONIC AMINO-ACID-TRANSPORT IN MAMMALIAN-CELLS
Autore:
AVILACHAVEZ E; TORRESYTORRES N; TOVARPALACIO A;
Indirizzi:
INST NACL NUTR SALVADOR ZUBIRAN,DEPT FISIOL NUTR,AREA NUTRIOL MOL,VASCO QUIROGA 15 MEXICO CITY 14000 DF MEXICO INST NACL NUTR SALVADOR ZUBIRAN,DEPT FISIOL NUTR,AREA NUTRIOL MOL MEXICO CITY 14000 DF MEXICO
Titolo Testata:
Revista de Investigacion Clinica
fascicolo: 4, volume: 49, anno: 1997,
pagine: 323 - 338
SICI:
0034-8376(1997)49:4<323:ZAIM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
SPA
Soggetto:
ISOLATED RAT HEPATOCYTES; HAMSTER OVARY CELLS; BLOOD-BRAIN-BARRIER; CULTURED HUMAN-FIBROBLASTS; PLASMA-MEMBRANE VESICLES; EPIDERMAL GROWTH-FACTOR; HIGH-AFFINITY COMPONENT; FETAL HUMAN-FIBROBLASTS; XENOPUS-LAEVIS OOCYTES; L-GLUTAMINE TRANSPORT;
Keywords:
AMINO ACIDS; TRANSPORT; SYSTEM A; SYSTEM ASC; SYSTEM L; SYSTEM BETA; SYSTEM GLY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
173
Recensione:
Indirizzi per estratti:
Citazione:
E. Avilachavez et al., "ZWITTERIONIC AMINO-ACID-TRANSPORT IN MAMMALIAN-CELLS", Revista de Investigacion Clinica, 49(4), 1997, pp. 323-338

Abstract

Amino acid transport is an important metabolic process that regulatesthe amino acid flux between the extracellular and intracellular spaceof the cell. Amino acids enter to the cell through plasmatic membraneproteins that have been kinetically well characterized. System A is involved in the transport of zwitterionic amino acids with short lateral chains and plays a key role in the gluconeogenesis from amino acids,especially from alanine, and has been implicated in the process of cellular duplication. System N transports amino acids with a nitrogen side chain, specially glutamine, an important regulator of protein synthesis. System L allows the entrance of zwitterionic amino acids with large side chains: it is normally constitutive and it is important for the uptake of these amino acids into the brain where some of them are precursors of neurotransmitters. Amino acid transport has been studied at a molecular level since several cDNAs have been cloned opening the possibility to study their structure and regulation. Several isoforms of some zwitterionic amino acids have been cloned including systems ASC, Gly, beta and proline, which have been classified as a superfamily of carrier proteins containing 6 to 12 spanning membrane domains. Thisreview shows the general aspects of amino acid transport and recent advances in the zwitterionic amino acid transport systems, emphasizing the molecular characteristics of cloned systems and their regulatory factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:08:54