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Titolo:
SYMPATHETIC ACTIVITY, BLOOD-PRESSURE VARIABILITY AND END-ORGAN DAMAGEIN HYPERTENSION
Autore:
MANCIA G; DIRIENZO M; PARATI G; GRASSI G;
Indirizzi:
UNIV MILAN,OSPED S GERARDO TINTORI,CATTEDRA MED INTERNA 1,VIA DONIZETTI 103 MONZA MILANO ITALY
Titolo Testata:
Journal of human hypertension
, volume: 11, anno: 1997, supplemento:, 1
pagine: 3 - 8
SICI:
0950-9240(1997)11:<3:SABVAE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIAL ARTERY COMPLIANCE; CORONARY VASOCONSTRICTION; FOLLOW-UP; SMOKING; HUMANS; NOREPINEPHRINE; CATECHOLAMINES; HYPERTROPHY; ACTIVATION; DISEASE;
Keywords:
ESSENTIAL HYPERTENSION; OBESITY; SYMPATHETIC NERVOUS SYSTEM; END ORGAN DAMAGE; BLOOD PRESSURE VARIABILITY; ANTIHYPERTENSIVE TREATMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
G. Mancia et al., "SYMPATHETIC ACTIVITY, BLOOD-PRESSURE VARIABILITY AND END-ORGAN DAMAGEIN HYPERTENSION", Journal of human hypertension, 11, 1997, pp. 3-8

Abstract

Animal studies have provided clearcut evidence that sympathetic factors are involved in the development and maintenance of high blood pressure (BP), This also appears to be the case in humans, in which sympathetic activation, detected through plasma noradrenaline measurement, noradrenaline spillover technique and direct recording of muscle sympathetic nerve activity, has been shown to characterize the early phases of the hypertensive state and parallel its severity, Sympathetic factors also play in a variety of pathophysiological states frequently associated with hypertension, such as obesity, insulin resistance and atherosclerosis, In addition evidence has been collected that adrenergic factors represent one of the mechanisms involved in determining BP variability, which is strictly associated with end organ damage, Taken together these findings underline the importance that the therapeutical approach to hypertension is aimed not only at lowering BP but also at reducing sympathetic activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:48:49