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Titolo:
AUTONOMIC NERVOUS-SYSTEM MARKERS OF PSYCHOPATHOLOGY IN CHILDHOOD-ONSET SCHIZOPHRENIA
Autore:
ZAHN TP; JACOBSEN LK; GORDON CT; MCKENNA K; FRAZIER JA; RAPOPORT JL;
Indirizzi:
NIMH,LAB BRAIN & COGNIT,FED BLDG,ROOM B1A14,7550 WISCONSIN AVE BETHESDA MD 20892 NIMH,CHILD PSYCHIAT BRANCH BETHESDA MD 20892
Titolo Testata:
Archives of general psychiatry
fascicolo: 10, volume: 54, anno: 1997,
pagine: 904 - 912
SICI:
0003-990X(1997)54:10<904:ANMOPI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDUCTANCE ORIENTING RESPONSE; SKIN-CONDUCTANCE; ELECTRODERMAL ACTIVITY; SPONTANEOUS FLUCTUATIONS; CLINICAL STATE; CHILDREN; CLOZAPINE; SYMPTOMATOLOGY; DEPRESSION; FLUPHENAZINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
T.P. Zahn et al., "AUTONOMIC NERVOUS-SYSTEM MARKERS OF PSYCHOPATHOLOGY IN CHILDHOOD-ONSET SCHIZOPHRENIA", Archives of general psychiatry, 54(10), 1997, pp. 904-912

Abstract

Background: Consistent abnormalities in peripheral indicators of autonomic activity, ie, skin conductance (SC) and heart rate (HR), have been reported in adult-onset schizophrenia. Herein, we use these markersto test the hypothesis of continuity between childhood-onset schizophrenia and adult-onset schizophrenia. Methods: Skin conductance and HR were recorded from 21 severely ill children and adolescents (mean age,14.1 years) with childhood-onset (less than or equal to 12 years) schizophrenia (patient group) and from 54 age-matched controls (control group) during a rest period, a series of innocuous tones, reaction timeinsructions, and a simple warned reaction time task. Results: During rest, patients had higher rates of spontaneous SC responses (SCRs) andHRs than controls, but their SC level was marginally lower and declined more slowly over time. Half of the patients, compared with 4% of the controls, failed to give SC-orienting responses to the first 2 tones. Patients who responded had impaired SCR magnitudes, and their habituation was more erratic than that of controls. The increase in SC leveland SCR frequency at the onset of the task period was greatly attenuated in the patients, so that both variables were higher in controls. Patients bad smaller SCRs and anticipatory HR responses to the reactiontime stimuli. Skin conductance nonresponding was associated with negative and total symptoms, and spontaneous SCR frequency was associated with positive symptoms. Conclusions: The findings show similar abnormalities in autonomic nervous system activity in childhood-onset schizophrenia to those found in adult chronic schizophrenia, thus supporting the hypothesis of continuity of the childhood and adult forms of the illness. Comparisons with data from other childhood disorders suggest that the combination of low-elicited SC activity with high levels of spontaneous SC activity may be specific to schizophrenia.

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Documento generato il 25/11/20 alle ore 06:27:48