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Titolo:
INTERLEUKIN-2 RECEPTOR-BETA AND GAMMA-CHAIN DYSREGULATION DURING THE INHIBITION OF CD4 T-CELL ACTIVATION BY HUMAN IMMUNODEFICIENCY VIRUS-1 GP120
Autore:
BANI L; DAVID D; FEVRIER M; PIALOUX G; DUPONT B; SUGAMURA K; THEZE J;
Indirizzi:
INST PASTEUR,DEPT IMMUNOL,UNITE IMMUNOGENET CELLULAIRE,25 RUE DR ROUXF-75724 PARIS 15 FRANCE INST PASTEUR,DEPT IMMUNOL,UNITE IMMUNOGENET CELLULAIRE F-75724 PARIS 15 FRANCE INST PASTEUR,DEPT RETROVIRUS,UNITE VIROL IMMUNOL CELLULAIRE PARIS FRANCE TOHOKU UNIV,SCH MED,DEPT MICROBIOL SENDAI MIYAGI 980 JAPAN HOP LOUIS PASTEUR PARIS FRANCE
Titolo Testata:
European Journal of Immunology
fascicolo: 9, volume: 27, anno: 1997,
pagine: 2188 - 2194
SICI:
0014-2980(1997)27:9<2188:IRAGDD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-INFECTED PATIENTS; TYROSINE PHOSPHORYLATION; ENVELOPE GLYCOPROTEIN; PERIPHERAL-BLOOD; DOWN-REGULATION; AIDS PATIENTS; EXPRESSION; LYMPHOCYTES; TYPE-1; ANTIBODIES;
Keywords:
INTERLEUKIN-2 RECEPTOR BETA; INTERLEUKIN-2 RECEPTOR GAMMA; CD4 T LYMPHOCYTE; HIV-1 GP120;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
L. Bani et al., "INTERLEUKIN-2 RECEPTOR-BETA AND GAMMA-CHAIN DYSREGULATION DURING THE INHIBITION OF CD4 T-CELL ACTIVATION BY HUMAN IMMUNODEFICIENCY VIRUS-1 GP120", European Journal of Immunology, 27(9), 1997, pp. 2188-2194

Abstract

We have observed that CD4 T lymphocytes from human immunodeficiency virus (HIV)-infected patients marginally express interleukin-2 receptor(IL-2R)beta and IL-2R gamma chains which are essential for IL-2 signal transduction. To analyze this observation further, we studied the influence of gp120 on the cell surface expression of IL-2R beta and IL-2R gamma by purified CD4 lymphocyte in vitro. Cross-linking of the T cell receptors of these lymphocytes initiates entry into the cell cycle as measured by CD69 and CD71 cell surface expression and [H-3]thymidine incorporation. It also induces the cell surface expression of IL-2R beta and IL-2R gamma. We have shown that treatment of the CD4 T lymphocytes with HIV-1 gp120 before anti-CD3 stimulation impedes cell cycle progression as measured by reduced CD71 expression and inhibition of [H-3]thymidine incorporation, Furthermore, cell surface expression of IL-2R beta and IL-2R gamma subunits, which form the functional intermediate-affinity IL-2R, are significantly inhibited. More importantly, addition of exogenous IL-2 does not restore the proliferation of the CD4T cells treated with gp120, suggesting that cells are anergic and/or that the remaining IL-2R are not functional. This is the first study of IL-2R beta and IL-2R gamma dysrcgulation in the context of HIV infection and shows that CD4 is also involved in IL-2R expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:01:28