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Titolo:
APOPTOSIS - CLINICAL RELEVANCE AND PHARMACOLOGICAL MANIPULATION
Autore:
THATTE U; DAHANUKAR S;
Indirizzi:
SETH GS MED COLL,DEPT PHARMACOL MUMBAI 400012 INDIA
Titolo Testata:
Drugs
fascicolo: 4, volume: 54, anno: 1997,
pagine: 511 - 532
SICI:
0012-6667(1997)54:4<511:A-CRAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; COLONY-STIMULATING FACTOR; BREAST-CANCER CELLS; ENDOGENOUS ENDONUCLEASE ACTIVATION; GLUCOCORTICOID-INDUCED APOPTOSIS; FAMILIAL ADENOMATOUS POLYPOSIS; SYSTEMIC LUPUS-ERYTHEMATOSUS; HUMAN GLIOBLASTOMA CELLS; MYELOID-LEUKEMIA CELLS; TUMOR-NECROSIS-FACTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
197
Recensione:
Indirizzi per estratti:
Citazione:
U. Thatte e S. Dahanukar, "APOPTOSIS - CLINICAL RELEVANCE AND PHARMACOLOGICAL MANIPULATION", Drugs, 54(4), 1997, pp. 511-532

Abstract

Apoptosis, often synonymously used with the term 'programmed cell death', is an active, genetically controlled process that removes unwanted or damaged cells. Suppression, overexpression or mutation of a number of genes which orchestrate the apoptotic process are associated withdisease, The diseases in which apoptosis has been implicated can be grouped into 2 broad groups: those in which there is increased cell survival (i.e. associated with inhibition of apoptosis) and those in which there is excess cell death (where apoptosis is overactive). Diseasesin which there is an excessive accumulation of cells include cancer, autoimmune disorders and viral infections. Deprivation of trophic factors is known to induce apoptosis in cells dependent on them for survival, This fact has been exploited in the use of antiandrogens or antiestrogens in the management of prostate or breast cancer. Haemopoietic growth factors like granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-3 prevent apoptosis in target cells and modulation of levels of these factors has been tried in the prevention of chemotherapy-induced myelosuppression, Until recently, it was thought thatcytotoxic drugs killed target cells directly by interfering with somelife-maintaining function. However, of late. it has been shown that exposure to several cytotoxic drugs with disparate mechanisms of actioninduces apoptosis in both malignant and normal cells. Physiological regulation of cell death is essential for the removal of potentially autoreactive lymphocytes during development and the removal of excess cells after the completion of an immune response. Recent work has clearly demonstrated that dysregulation of apoptosis may underlie the pathogenesis of autoimmune diseases by allowing abnormal autoreactive lymphocytes to survive. AIDS and neurodegenerative disorders like Alzheimer's or Parkinson's disease represent the most widely studied group of disorders where an excess of apoptosis has been implicated. Amyotrophic lateral sclerosis, retinitis pigmentosa, epilepsy and alcoholic brain damage an other neurological disorders in which apoptosis has been implicated. Apoptosis has been reported to occur in conditions characterised by ischaemia, e.g. myocardial infarction and stroke. The liver is a site where apoptosis occurs normally. This process has also been implicated in a number of liver disorders including obstructive jaundice. Hepatic damage due to toxins and drugs is also associated with apoptosis in hepatocytes. Apoptosis has also been identified as a key phenomenon in some diseases of the kidney, i.e, polycystic kidney, as well as in disorders of the pancreas like alcohol-induced pancreatitis and diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:26:30