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Titolo:
SEARCH FOR DNA-REPAIR INHIBITORS - SELECTIVE BINDING OF NUCLEIC BASESACRIDINE CONJUGATES TO A DNA DUPLEX CONTAINING AN ABASIC SITE
Autore:
BERTHET N; CONSTANT JF; DEMEUNYNCK M; MICHON P; LHOMME J;
Indirizzi:
UNIV GRENOBLE 1,UMR CNRS 5616,LEDSS,BP 53 F-38041 GRENOBLE 9 FRANCE UNIV GRENOBLE 1,UMR CNRS 5616,LEDSS F-38041 GRENOBLE 9 FRANCE
Titolo Testata:
Journal of medicinal chemistry
fascicolo: 21, volume: 40, anno: 1997,
pagine: 3346 - 3352
SICI:
0022-2623(1997)40:21<3346:SFDI-S>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLEAVE APURINIC SITES; DEOXYRIBONUCLEIC-ACID; APYRIMIDINIC SITES; ESCHERICHIA-COLI; ENDONUCLEASES; MOLECULES; OLIGODEOXYNUCLEOTIDES; 9-AMINO-ELLIPTICINE; THERMODYNAMICS; DEPURINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
N. Berthet et al., "SEARCH FOR DNA-REPAIR INHIBITORS - SELECTIVE BINDING OF NUCLEIC BASESACRIDINE CONJUGATES TO A DNA DUPLEX CONTAINING AN ABASIC SITE", Journal of medicinal chemistry, 40(21), 1997, pp. 3346-3352

Abstract

The abasic site is one of the most frequent DNA lesions generated by spontaneous or enzymatic cleavage of the N-glycosidic bond. The abasicsite is also an intermediate in the nucleotide and base excision DNA repair. We examined molecules which recognize and cleave DNA at the abasic site with high efficiency. These molecules incorporate in their structure a nucleic base for abasic site recognition, an intercalator for DNA binding, and a polyamino linker for ionic interaction and DNA cleavage. Such compounds, by interfering with abasic sites in DNA, are also inhibitors of DNA repair. In order to better understand the parameters of the interaction, we carried out a UV thermal denaturation study of synthetic oligonucleotides containing the lesion both in the absence and in the presence of the drugs. A similar study was also carried out using the corresponding nonmodified oligonucleotide. The resultsindicate selective binding of the base-chain-intercalator conjugates to the abasic site containing oligonucleotides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 08:13:07