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Titolo:
RESPONSES OF CATECHOLESTROGEN METABOLISM TO ACUTE GRADED-EXERCISE IN NORMAL MENSTRUATING WOMEN BEFORE AND AFTER TRAINING
Autore:
DECREE C; BALL P; SEIDLITZ B; VANKRANENBURG G; GEURTEN P; KEIZER HA;
Indirizzi:
INST GYNECOENDOCRINOL RES,DEPT APPL & EXPT REPROD ENDOCRINOL B-3000 LOUVAIN BELGIUM UNIV LUBECK,DEPT BIOCHEM & CLIN ENDOCRINOL D-23538 LUBECK GERMANY UNIV MAASTRICHT,FAC HLTH SCI,DEPT MOVEMENT SCI NL-6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 10, volume: 82, anno: 1997,
pagine: 3342 - 3348
SICI:
0021-972X(1997)82:10<3342:ROCMTA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE; PHYSICAL EXERCISE; CYCLE PHASE; LH-RELEASE; CATECHOLAMINES; SECRETION; GONADOTROPIN; PERFORMANCE; ESTROGENS; RUNNERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C. Decree et al., "RESPONSES OF CATECHOLESTROGEN METABOLISM TO ACUTE GRADED-EXERCISE IN NORMAL MENSTRUATING WOMEN BEFORE AND AFTER TRAINING", The Journal of clinical endocrinology and metabolism, 82(10), 1997, pp. 3342-3348

Abstract

It has been hypothesized that exercise-related hypo-estrogenemia occurs as a consequence of increased competition of catecholestrogens (CE)for catechol-O-methyltransferase (COMT). This may result in higher norepinephrine (NE) concentrations, which could interfere with normal gonadotropin pulsatility. The present study investigates the effects of training on CE responses to acute exercise stress. Nine untrained eumenorrheic women (mean percentage of body fat +/-SD: 24.8 +/- 3.1%) volunteered for an intensive 5-day training program. Resting, submaximal, and maximal (t(max)) exercise plasma CE, estrogen, and catecholamine responses were determined pre-and post training in both the follicular (FPh) and luteal phase (LPh). Acute exercise stress increased total primacy estrogens (E) but had little effect on total 2-hydroxyestrogens (2-OHE) and 2-hydroxyestrogen-monomethylethers (2-MeOE) (= O-methylated CE after competition for catechol-O-methyltransferase). This patternwas not significantly changed by training. However, posttraining LPh mean (+/- SE) plasma E, 2-OHE, and 2-MeOE concentrations were sig nificantly lower (P < 0.05) at each exercise intensity (for 2-OHE: 332 +/-47 vs. 422 +/- 57 pg/mL at t(max); for 2-MeOE: 317 +/- 26 vs. 354 +/-34 pg/mL at t(max)). Training produced opposite effects on 2-OHE:E ratios (an estimation of CE formation) during acute exercise in the FPh (reduction) and LPh (increase). The 2-MeOE:2-OHE ratio (an estimation of CE activity) showed significantly higher values at t(max) in both menstrual phases after training (FPh: + 11%; LPh: +23%; P < 0.05). After training, NE values were significantly higher (P < 0.05). The major findings of this study were that: training lowers absolute concentrations of plasma estrogens and CE; the acute exercise challenge altered plasma estrogens but had little effect on CE; estimation of the formation and activity of CE suggests that formation and O-methylation of CE proportionately increases. These findings may be of importance for NE-mediated effects on gonadotropin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:57:01