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Titolo:
REVERSAL OF THE SEX DIFFERENCE IN SERUM LEPTIN LEVELS UPON CROSS-SEX HORMONE ADMINISTRATION IN TRANSSEXUALS
Autore:
ELBERS JMH; ASSCHEMAN H; SEIDELL JC; FROLICH M; MEINDERS AE; GOOREN LJG;
Indirizzi:
FREE UNIV AMSTERDAM HOSP,DIV ENDOCRINOL ANDROL,POB 7057 NL-1007 MB AMSTERDAM NETHERLANDS NATL INST PUBL HLTH & ENVIRONM PROTECT,DEPT CHRON DIS & ENVIRONM EPIDEMIOL NL-3720 BA BILTHOVEN NETHERLANDS UNIV LEIDEN HOSP,DEPT CLIN CHEM NL-2300 RC LEIDEN NETHERLANDS UNIV LEIDEN HOSP,DEPT INTERNAL MED NL-2300 RC LEIDEN NETHERLANDS
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 10, volume: 82, anno: 1997,
pagine: 3267 - 3270
SICI:
0021-972X(1997)82:10<3267:ROTSDI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA LEPTIN; OBESE GENE; WEIGHT; ADIPOSITY; PROTEIN; HUMANS; GENDER; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.M.H. Elbers et al., "REVERSAL OF THE SEX DIFFERENCE IN SERUM LEPTIN LEVELS UPON CROSS-SEX HORMONE ADMINISTRATION IN TRANSSEXUALS", The Journal of clinical endocrinology and metabolism, 82(10), 1997, pp. 3267-3270

Abstract

Women have higher circulating leptin levels than men. This sex difference is not simply explained by differences in the amount of body fat and is possibly influenced by their different sex steroid milieus. This prompted us to study prospectively the effects of cross-sex steroid hormones on serum leptin levels in 17 male to female transsexuals and 15 female to male transsexuals. Male to female transsexuals were treated with 100 mu g ethinyl estradiol and 100 mg cyproterone acetate (antiandrogen) daily, and female to male transsexuals received testosterone esters (250 mg/2 weeks, im). Before and after 4 and 12 months of cross-sex hormone treatment, serum leptin levels and measures of body fatness were assessed. Before treatment, female subjects had higher serumleptin levels than male subjects independently of the amount of body fat (P < 0.01). Cross-sex hormone administration induced a reversal ofthe sex difference in serum leptin levels. Estrogen treatment in combination with antiandrogens in male subjects increased median serum leptin levels from 1.9 ng/mL before treatment to 4.8 ng/mL after 4 monthsand 5.5 ng/mL after 12 months of treatment (P < 0.0001). Testosteroneadministration in female subjects decreased median serum leptin levels from 5.6 to 2.6 ng/mL after 4 months and to 2.5 ng/mL after 12 months (P < 0.0001). Analysis of covariance revealed that the changes in serum leptin levels were independent of Changes in body fatness in both groups (P < 0.01). In conclusion, these results indicate that sex steroid hormones, in particular testosterone, play an important role in the regulation of serum leptin levels. The prevailing sex steroid milieu, not genetic sex, is a Significant determinant of the sex difference in serum leptin levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 14:13:53